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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳志傑(Chih-Chieh Chen) | |
dc.contributor.author | Wan-Ting Lin | en |
dc.contributor.author | 林婉婷 | zh_TW |
dc.date.accessioned | 2021-05-20T21:03:27Z | - |
dc.date.available | 2011-10-03 | |
dc.date.available | 2021-05-20T21:03:27Z | - |
dc.date.copyright | 2011-10-03 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-07-14 | |
dc.identifier.citation | Almstrand A-C, Bake B, Ljungström E, Larsson P, Bredberg A, Mirgorodskaya E, Olin A-C. 2010. Effect of airway opening on production of exhaled particles. Journal of Applied Physiology 108:584.
ATS. 1991. Lung Function Testing: Selection of Reference Values and Interpretative Strategies. 144:1202-1218. Barton A, Lourenço R. 1973. Bronchial secretions and mucociliary clearance.Biochemical characteristics. Archives of Internal Medicine 131:140-144. Basser PJ, McMahon TA, Griffith P. 1989. The Mechanism of Mucus Clearance in Cough. Journal of Biomechanical Engineering 111:288-297. Brogan T. 1960. The high molecular weight components of sputum. British journal of experimental pathology 41 288 -297. Brusasco V, Crapo R, Viegi G. 2005a. Standardisation of spirometry. European Respiratory Journal 26:319-338. Brusasco V, Crapo R, Viegi G. 2005b. Standardisation of the measurement of lung volumes. European Respiratory Journal 26:511-522. CDC. 1994. Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care facilities. Morbidity and Mortality Weekly Report (MMWR) 43. Celli BR, MacNee W, members c. 2004. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. European Respiratory Journal 23:932-946. Chao CYH, Wan MP, Morawska L, Johnson GR, Ristovski ZD, Hargreaves M, Mengersen K, Corbett S, Li Y, Xie X, Katoshevski D. 2009. Characterization of expiration air jets and droplet size distributions immediately at the mouth opening. Journal of Aerosol Science 40:122-133. Cole EC, Cook CE. 1998. Characterization of infectious aerosols in health care facilities: An aid to effective engineering controls and preventive strategies. American Journal of Infection Control 26:453-464. Duguid JP, M.B., B.Sc. 1946. The Size and the Duration of Air-Carriage of Respiratory Droplets and Droplet-Nuclei. The Journal of Hygiene 44:471-479. Edwards DA. 2006. Inhaling cationic aerosols to mitigate the spread of infectious disease. Evrensel CA, Khan MRU. 2003. Interaction of laminar airflow with viscoelastic airway mucus. Technology and Health Care 11:149. Evrensel CA, Khan MRU, Elli S, Krumpe PE. 1993. Viscous Airflow Through a Rigid Tube With a Compliant Lining: A Simple Model for the Air-Mucus Interaction in Pulmonary Airways. Journal of Biomechanical Engineering 115:262. Fabian P, Brain J, Houseman EA, Gern J, Milton DK. 2011. Origin of Exhaled Breath Particles from Healthy and Human Rhinovirus-Infected Subjects. Journal of Aerosol Medicine and Pulmonary Drug Delivery 24:1-11. Fabian P, McDevitt JJ, DeHaan WH, Fung RO, Cowling BJ, Chan KH, Leung GM, Milton DK. 2008. Influenza virus in human exhaled breath: an observational study. PLoS ONE 3. Fairchild CI, Stampfer JF. 1987. Particle Concentration in Exhaled Breath. American Industrial Hygiene Association Journal 48:948 - 949. Gupta JK, Lin CH, Chen Q. 2009. Flow dynamics and characterization of a cough. Indoor Air 19:517-525. Haefeli-Bleuer B, Weibel ER. 1988. Morphometry of the human pulmonary acinus. The Anatomical Record 220:401-414. Hassan AA, Evrensel CA, Krumpe PE. 2006. Clearance of viscoelastic mucus simulant with airflow in a rectangular channel, an experimental study. Technology and Health Care 14:1. Hirsch S. 1975. The Role of Mucus in Asthma. New directions in asthma. Holmgren H, Bake B, Olin A-C, Ljungström E. 2011. Relation Between Humidity and Size of Exhaled Particles. Journal of Aerosol Medicine and Pulmonary Drug Delivery 24:1-8. Holmgren H, Ljungström E, Almstrand A-C, Bake B, Olin A-C. 2010. Size distribution of exhaled particles in the range from 0.01 to 2.0 [mu]m. Journal of Aerosol Science 41:439-446. Johnson GR, Morawska L. 2009. The mechanism of breath aerosol formation. J Aerosol Med Pulm Drug Deliv 22:229-237. Kaliner M, Marom Z, Patow C, Shelhamer J. 1984. Human respiratory mucus. Journal of Allergy and Clinical Immunology 73:318-323. Kilburn KH. 1968. A hypothesis for pulmonary clearance and its implications. American Review of Respiratory Disease 98:449-463. Kim CS, Greene MA, Sankaran S, Sackner MA. 1986. Mucus transport in the airways by two-phase gas-liquid flow mechanism: continuous flow model. Journal of Applied Physiology 60:908. Kim CS, Iglesias AJ, Sackner MA. 1987. Mucus clearance by two-phase gas-liquid flow mechanism: asymmetric periodic flow model. Journal of Applied Physiology 62:959. King M, Brock G, Lundell C. 1985. Clearance of mucus by simulated cough. Journal of Applied Physiology 58:1776. Lippmann M. 1995. Size-Selective Health Hazard Sampling 8th ed. Cincinnati: ACGIH. Lopez-Vidriero MT. 1981. Airway mucus; production and composition. CHEST 80:799. Malashenko A, Tsuda A, Haber S. 2009. Propagation and Breakup of Liquid Menisci and Aerosol Generation in Small Airways. J Aerosol Med Pulm Drug Deliv. Marom ZM, Goswami SK. 1991. Respiratory mucus hypersecretion (bronchorrhea): A case discussion--possible mechanism(s) and treatment. Journal of Allergy and Clinical Immunology 87:1050-1055. Marriott C. 1990. Mucus and mucociliary clearance in the respiratory tract. Advanced Drug Delivery Reviews 5:19-35. Morawska L, Johnson GR, Ristovski ZD, Hargreaves M, Mengersen K, Corbett S, Chao CYH, Li Y, Katoshevski D. 2009. Size distribution and sites of origin of droplets expelled from the human respiratory tract during expiratory activities. Journal of Aerosol Science 40:256-269. Moriarty JA, Grotberg JB. 1999. Flow-induced instabilities of a mucus–serous bilayer. Journal of Fluid Mechanics 397:1. Nicas M, Nazaroff WW, Hubbard A. 2005. Toward Understanding the Risk of Secondary Airborne Infection: Emission of Respirable Pathogens. Journal of Occupational and Environmental Hygiene 2:143 - 154. Papineni RS, Rosenthal FS. 1997. The size distribution of droplets in the exhaled breath of healthy human subjects. J Aerosol Med 10:105-116. Pauwels RA, Buist AS, Calverley PMA, Jenkins CR, Hurd SS. 2001. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop Summary. Am. J. Respir. Crit. Care Med.163:1256-1276. Richardson P. 1980. The physical and chemical properties of airway mucus and their relation to airway function. European journal of respiratory diseases 111:13-15. Ross BB, R G, H R. 1955. Physical dynamics of the cough mechanism. Journal of Applied Physiology 8:264-268. Schans CPvd. 2007. Bronchial mucus transport. Respir Care 52:1150-1156. Schwarz K, Heike Biller MD, Windt H, Wolfgang Koch PD, Jens M. Hohlfeld MD. 2010. Characterization of Exhaled Particles from the Healthy Human Lung—A Systematic Analysis in Relation to Pulmonary Function Variables. Journal of Aerosol Medicine and Pulmonary Drug Delivery 23:371. Tellier R. 2009. Aerosol transmission of influenza A virus: a review of new studies. In: Journal of The Royal Society Interface. p S783-S790. Weibel ER. 1963. Morphometry of the Human Lung. New York: Academic Press. West JB. 2008. Respiratory physiology: the essentials 8th ed. WHO. 2003. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. WHO. 2010. WHO Weekly Epidemiological Record on 23 July 2010 Xie X, Li Y, Chwang ATY, Ho PL, Seto WH. 2007. How far droplets can move in indoor environments - revisiting the Wells evaporation-falling curve. Indoor Air 17:211-225. Yang S, Lee GW, Chen CM, Wu CC, Yu KP. 2007. The size and concentration of droplets generated by coughing in human subjects. J Aerosol Med 20:484-494. Zhu S, Kato S, Yang J-H. 2006. Study on transport characteristics of saliva droplets produced by coughing in a calm indoor environment. Building and Environment 41:1691-1702. 行政院衛生署疾病管制局. 2010. 流感疫情每日摘要. 郭婉琦. 2009. 呼出氣體中流行性感冒病毒與腸病毒之偵測. In: 公共衛生學研究所. 高雄市: 高雄醫學大學. p 129. 顏稚浩. 2010. 監測人體呼吸道產生微粒之系統建置. In: Development of an Exhaled Breath Aerosol Monitoring System: 臺灣大學. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/10120 | - |
dc.description.abstract | 傳統上,認為呼吸道疾病的傳播方式是經由病患咳嗽或打噴嚏所產生的生物氣膠所引起,事實上,咳嗽及打噴嚏的動作是易引起周遭人群注意及迴避的,因這兩種傳播方式會引起較大聲響,且產生之液滴為高濃度及粒徑亦較大。然而,近幾年許多研究發現,人體在「安靜的」正常呼吸下亦能產生微粒,因此,認為正常呼吸在呼吸道疾病傳播上亦扮演重要的角色,特別是在較擁擠的公共場所及醫療場所。目前研究發現人體呼出微粒(Exhaled Breath Aerosol, EBA)的產生機制有兩種,一為因呼吸道中的紊流將呼吸道管壁上的黏液捲起而產生氣懸膠隨後被呼出(Turbulence induced aerosolization);另一種機制為細支氣管液體薄膜破裂模式(Bronchiole Fluid Film Burst, BFFB)。本研究之目的是利用已建置完成之人體呼出微粒監測系統以達到:(1) 驗證過去文獻提出之肺部產生微粒之機制。(2) 探討呼出微粒濃度與呼吸型態及肺功能參數間之相關性。(3) 比較受試者在健康及感冒狀態下,呼出微粒濃度之變化情形。
以閉氣方式證實一般呼吸產生的微粒主要是因收縮的小支氣管再次打開所形成,且產生於吸氣階段。每口呼氣的微粒數隨潮氣容積增加而增加,但呼吸頻率無明顯影響,推論是因潮氣容積增加時,會使收縮及再打開的細支氣管數量增加,而此現象與頻率無關;在相同呼吸條件下,不同受試者間每口呼氣的微粒數有顯著差異,但同一受試者在相同呼吸條件且不同時間下,每口呼氣的微粒數的再現性高,可能因個體間的氣管中黏液特性及呼吸道構造不同所致。粒徑分佈眾數為0.3微米,有高達90%的微粒為次微米的粒徑,且不同受試者間無明顯差異。另外,在健康與感冒狀態下的呼出微粒濃度比較方面,同一受試者在相同條件下,感冒時會呼出較高濃度的微粒,約高出20~50%,認為可能與呼吸道中的黏液特性發生變化有關,而此狀況的產生對於醫療院所的照護者是一大威脅。 | zh_TW |
dc.description.abstract | Coughing and sneezing are known to spread respiratory diseases. The aerosol outputs by coughing and sneezing are visible because of the high number concentration and large micro-metered size. Coughing and sneezing can be loud and irritating to people around, which is good because it alerts people to stay away. In contrast to these audible and visible aerosol generation mechanisms, several recent studies reported that “silent” tidal breathing can also generate aerosols. This might play a more important role in disease transmission, especially in intensive care and emergency care units. Two aerosol generation mechanisms were proposed in previous studies: the turbulence induced aerosolization and the Bronchiole Fluid Film Burst (BFFB). The main objectives of the present study were (1) to verify the proposed lung aerosol generation mechanisms, (2) to study the dependency of exhaled breath aerosol on breathing pattern and other lung function variables, and (3) to characterize the differences in exhaled breath aerosols between healthy and sick conditions of the same subjects.
The results supported the hypothesis of BFFB through a breath-holding technique. The EBA (Exhaled Breath Aerosol) count per breath increased with increasing tidal volume. However, breathing frequency did not affect EBA generation. We speculated that this is due the number of closing-up and re-opening terminal bronchioles increased with increasing tidal volume. This number apparently is independent of breathing frequency. The between-subject variation is much higher than the within-subject variation, indicating that the mucus properties and the respiratory tract structure vary more significantly among subjects. The EBA of all tested subjects showed similar size distribution, with a count median diameter of 0.3 micrometer and GSD of 2.4. When subjects were sick, they tended to generate more exhaled breath aerosols, showing 20 to 50% increase in count per breath, a bad news to health-care workers. | en |
dc.description.provenance | Made available in DSpace on 2021-05-20T21:03:27Z (GMT). No. of bitstreams: 1 ntu-100-R98844001-1.pdf: 6204319 bytes, checksum: da15ede8c4063cae925148f287b0e420 (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | 誌謝 I
摘要 II Abstract III 目錄 IV 圖目錄 VI 表目錄 VIII 附錄 IX 第一章、研究背景與目的 1 1.1 研究背景 1 1.2 研究目的 2 第二章、文獻回顧 3 2.1 呼吸系統構造及功能 3 2.2 呼吸系統黏液之功能特性 4 2.3 呼吸道疾病的傳播 5 2.4 人體產生微粒情形 7 2.5 可能之呼出微粒產生機制 8 2.6 肺容積與肺功能 10 第三章、材料與方法 12 3.1 實驗系統 12 3.1.1 人體呼出微粒監測系統 12 3.1.2 實驗儀器 13 3.2人體資料的收集 14 3.2.1 受試者及標準呼吸模式條件的選擇 15 3.2.2人體測試流程 16 3.3呼出微粒產生機制之驗證 17 3.4人體大量呼出微粒之方法 17 第四章、結果與討論 19 4.1 迫淨肺部中環境微粒之策略建議 19 4.2 確認人體試驗時間 19 4.3 不同呼吸條件、不同受試者呼出微粒情形 20 4.4 呼出微粒產生機制之驗證 22 4.5 人體大量產生微粒之方法 23 4.6 感冒對人體呼出微粒之影響 23 4.7 呼出微粒濃度與人口學資料、肺功能參數之相關性 24 第五章、結論 26 第六章、參考文獻 27 | |
dc.language.iso | zh-TW | |
dc.title | 人體呼出微粒監測系統之應用 | zh_TW |
dc.title | Applications of an Exhaled Breath Aerosol Monitoring System | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 蔡詩偉(Shih-Wei Tsai) | |
dc.contributor.oralexamcommittee | 蔡春進,吳惠東,許德仁 | |
dc.subject.keyword | 呼出微粒,潮氣容積,肺功能, | zh_TW |
dc.subject.keyword | exhaled particle,tidal volume,pulmonary function, | en |
dc.relation.page | 55 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2011-07-14 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 環境衛生研究所 | zh_TW |
顯示於系所單位: | 環境衛生研究所 |
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