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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 蕭浩明(Hao-Ming Hsiao) | |
dc.contributor.author | Guan-Jie Su | en |
dc.contributor.author | 蘇冠傑 | zh_TW |
dc.date.accessioned | 2021-07-11T14:38:22Z | - |
dc.date.available | 2022-07-25 | |
dc.date.copyright | 2017-08-29 | |
dc.date.issued | 2017 | |
dc.date.submitted | 2017-07-26 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/77961 | - |
dc.description.abstract | 由於醫學迅速的發展,傳統的裸金屬血管支架無法達到目前的醫療需求,而塗藥血管支架可以藉由負載藥物達到更有效的治療。於是塗藥血管支架在治療心血管疾病上扮演越來越重要的位置,且創新設計的儲藥槽式塗藥血管支架更是未來植入式醫療器材之流行新趨勢。未來不僅可以更有效的應用多種藥物在同一支血管支架上,更可以藉由控制釋放藥物的時間,使血管支架作為藥物載具有更高的發展潛力與可能性。不過現今的塗藥血管支架製造中,多是以噴霧式完成塗佈藥物。然而以人工塗佈藥物無法具有較高的穩定性,且噴霧式噴嘴大範圍塗佈會造成藥物的浪費。塗藥血管支架表面上如果過度塗佈,很容易對治療有不良影響。且目前的塗佈方式更是無法應用在儲藥槽式塗藥血管支架上。
由於塗佈流程是塗藥血管支架製造的最後一步,血管支架表面容易與原先的血管支架設計圖有差異,會無法完成指定位置的塗佈。為了克服上述的缺點,本研究設計、開發、實作出一臺新型的藥物載具自動塗佈系統。此系統中以自動化改善人工塗佈,更將噴霧式塗佈改為定點塗佈,並且可以應用在儲藥槽式塗藥血管支架上,達到階段性釋放的可能性。硬體部分是由精密移動控制機構、光學影像定位機構、藥物塗佈控制機構所設計整合完成。而軟體部分是利用C#、OpenCV、OpenGL,以及本研究自行整合開發的自動塗佈系統工具包(ACSTK)進行軟體與功能的撰寫,進而完成整個自動化系統的整合實現。 本研究首先應用機器視覺的技術為血管支架做影像建模定位,並且利用影像處理技術自動辨識出血管支架表面與儲藥槽的特徵,控制藥物塗佈控制機構進行定點塗佈。最後不同尺寸與型態的血管支架進行此自動化系統驗證,結果顯示本研究都可以成功地完成定位、塗佈等功能。本研究所設計之自動塗佈系統,除了可以應用在多種不同的血管支架上,也擁有多種塗佈功能,大大提升血管支架的價值。 | zh_TW |
dc.description.abstract | Thanks to the rapid development of medical devices, the drug-eluting stent plays more and more important role in the treatment of cardiovascular disease. Tradition bare metal stent have not met current requirements, and drug-eluting stent is able to provide more effective treatment by drug delivery. The novel drug-eluting stent design with micro-sized drug reservoirs (drug-eluting depot stent) will become the new trend of implantable medical equipment. Down the line, different types of medicine can be coated on a vascular stent, and physicians will be able to control release time of the medicine, empowering drug-eluting stents with more possibility and potential.
Currently, the coating of drug-eluding stent is processed manually with spray nozzle. However, manual handled coating does not make drug-eluting stent more stable, and spray nozzle causes waste of medicine due to the wide coating range. What is more serious that over-coating on the vascular stent surface could have bad impact on many treatments. In addition, the current coating method must not apply to depot drug-eluting stent, and does not achieve the novel treatment of releasing drugs with different stages. To combat the above disadvantages, this research designed and developed a new automatic coating system of drug delivery vehicles. This automatic system not only improved manual handling coating, but also changed spray nozzle to micro-glass nozzle to achieve target coating. With these significant improvements, the coating of depot drug-eluting stent became feasible. In this automatic system, the self-designed hardware was integrated with three mechanisms including the Precision Motion Control Mechanism, the Image Modeling and Position Mechanism and the Drug Coating Control Mechanism. The software was built with C-Sharp (C#) programming language and multiple libraries, including OpenCV, OpenGL, and the self-developed toolkit ACSTK. Then the integration of the entire the automation system was completed. Before the coating process, drug-eluting stent had to undergo a lot of manufacturing process such as heat treatment and electrical polishing. The drug-eluting stent actual surface and design surface could have much difference. Therefore, this research used vascular stent images to achieve image modeling and positioning with machine vision technology. Moreover, the system was able to automatically identify vascular stent and micro-sized drug reservoirs characteristics utilizing image processing. Finally, the system controlled the Drug Coating Control mechanism to complete target coating. The result had shown this research successfully developed the automatic coating system of drug delivery vehicles, and it can not only coat the current drug-eluting stents, but also able to apply to depot drug-eluting stents. It can even coat other different types of vascular stents. | en |
dc.description.provenance | Made available in DSpace on 2021-07-11T14:38:22Z (GMT). No. of bitstreams: 1 ntu-106-R04522810-1.pdf: 13547507 bytes, checksum: 53c4a604f3bf524f3254dd9983fa18e5 (MD5) Previous issue date: 2017 | en |
dc.description.tableofcontents | 口試委員審定書 i
誌謝 ii 摘要 iii ABSTRACT iv 目錄 vi 圖目錄 ix 表目錄 xiii 縮寫名詞對照表 xiv 第一章 緒論 1 1.1 前言 1 1.2 研究動機與目的 5 1.3 研究方法與架構 7 第二章 研究背景 8 2.1 血管支架概述 8 2.2 塗藥血管支架 10 2.3 儲藥槽式塗藥血管支架 11 2.4 文獻探討 12 第三章 機器視覺理論與應用 14 3.1 機器視覺簡介 14 3.2 影像擷取 15 3.2.1 光學攝影機 16 3.2.2 光學鏡頭 18 3.2.3 照明光源 19 3.3 影像處理分析 22 3.3.1 影像處理原理 23 3.3.2 基本影像處理 25 3.3.3 邊緣檢測演算法 29 3.3.4 隨機三點霍夫圓法 32 3.3.5 樣板比對演算法 34 3.4 機構控制 36 3.4.1 步進馬達分類 36 3.4.2 步進馬達控制理論 37 3.4.3 影像座標與單位轉換 38 第四章 自動化系統設計與實作 40 4.1 系統架構 42 4.1.1 硬體架構之設計開發 43 4.1.2 流程架構之設計開發 45 4.2 精密移動控制機構(PMCM) 47 4.2.1 控制平台 48 4.2.2 工作載台 50 4.2.3 馬達滑台組 53 4.3 光學影像定位機構(OIPM) 56 4.3.1 光學攝影機與鏡頭 57 4.3.2 影像線掃描重組法 59 4.3.3 照明光源與控制器 60 4.3.4 光學設備調整裝置 63 4.4 藥物塗佈控制機構(DCCM) 64 4.4.1 微型玻璃噴嘴 65 4.4.2 精密壓力調整裝置 66 4.4.3 脈波控制器 67 4.5 自動化系統軟體開發 68 4.5.1 軟體程式介面介紹 69 4.5.2 自動塗佈系統工具包 72 4.5.3 軟硬體溝通 73 4.6 影像建模定位流程 74 4.6.1 初始化 74 4.6.2 影像座標定位 75 4.6.3 影像組合與轉換 77 4.6.4 影像3D建模 79 4.7 藥物塗佈控制流程 80 4.7.1 快速塗佈法(RCM) 81 4.7.2 表面塗佈法(SCM) 82 4.7.3 定點塗佈法(TCM) 84 4.8 自動光學檢測流程 85 第五章 自動化系統測試與討論 86 5.1 測試研究樣本 86 5.2 自動化系統實作結果 88 5.3 精密移動控制機構測試 90 5.4 影像建模定位結果 91 5.5 藥物塗佈控制結果 93 第六章 結論與未來展望 97 6.1 結論 97 6.2 未來展望 98 參考文獻 100 附錄A 106 | |
dc.language.iso | zh-TW | |
dc.title | 應用機器視覺於藥物載具自動塗佈系統之設計與實現 | zh_TW |
dc.title | Design and Implementation of Automated Drug Coating System with Machine Vision | en |
dc.type | Thesis | |
dc.date.schoolyear | 105-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 廖英志(Ying-Chih Liao),莊嘉揚(Jia-Yang Juang) | |
dc.subject.keyword | 藥物載具,塗藥血管支架,機器視覺,影像建模定位,自動光學檢測, | zh_TW |
dc.subject.keyword | Drug delivery vehicles,Drug Eluting Stent,Machine Vision Technology,Image Modeling and Positioning,Automatic Optical Inspection, | en |
dc.relation.page | 108 | |
dc.identifier.doi | 10.6342/NTU201701871 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2017-07-27 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 機械工程學研究所 | zh_TW |
顯示於系所單位: | 機械工程學系 |
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