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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 蘇南維 | |
dc.contributor.author | Keng-Yu Chen | en |
dc.contributor.author | 陳耕右 | zh_TW |
dc.date.accessioned | 2021-07-10T22:04:42Z | - |
dc.date.available | 2021-07-10T22:04:42Z | - |
dc.date.copyright | 2018-08-21 | |
dc.date.issued | 2018 | |
dc.date.submitted | 2018-08-16 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/77491 | - |
dc.description.abstract | 存在於黃豆中的異黃酮是黃豆的二級代謝物,可與人體雌激素受體 (estrogens receptor) 結合,被稱為植物性雌激素 (phytoestrogens)。黃豆異黃酮依其化學結構不同,可分成四大類: malonyl-glucosides、acetyl-glucosides、glucosides和aglycones,其中以不帶醣基之異黃酮 (aglycones) 有較佳之生理活性。許多文獻指出屬於aglycones類的金雀異黃酮 (genistein) 具有預防骨質疏鬆、抗心血管疾病、乳癌及前列腺癌等多項生理活性。然而,根據 Biopharmaceutics Classification System (BCS) 分類,genistein 屬於第四類化合物─低水溶性,低穿透性,造成 genistein之生物可利用率 (bioavailability) 不佳。本研究室先前篩選出Bacillus subtilis BCRC 80517菌株可對genistein進行磷酸酯化修飾,形成genistein 7-O-phosphate (G7P)。 G7P不僅水溶性佳,且可增加genistein之生物可利用率。本研究透過 B. subtilis BCRC 80517 進行生物轉化,以 genistein 作為轉化基質,來生產 G7P,並探討放大發酵規模來評估生產 G7P的可行性。首先探討 5 公升發酵槽生產 G7P 的培養條件,進而探討利用控制溶氧、攪拌速率及消泡劑的使用等,採用饋料批次 (fed-batch) 發酵生產方式,有最佳的 G7P 轉換效率及產量,可於發酵時間 48 小時內,將 35 公克 genistein 轉化生成 G7P。放大至 50 公升,可於發酵時間 48 小時內,將 1260公克 genistein 轉化生成 G7P。 | zh_TW |
dc.description.abstract | Isoflavones are a group of plant secondary metabolites that occur mostly in the subfamily Papilionoideae of the Leguminosae. Soybean (Glycine max) is the most abundant source of isoflavones. To date, 12 natural isoflavones have been found in soybeans, consisting of 3 types of isoflavone aglycones (namely daidzein, genistein and glycitein), and their corresponding conjugates with glucose, acetylglucose and malonylglucose. Genistein has a number of pharmacological and biological activities, however, low water solubility and poor bioavailability limit its use. Our previous study revealed a water-soluble phosphate conjugate of genistein 7-O-phosphate (G7P), generated by biotransformation of Bacillus subtilis BCRC 80517 with genistein. In pharmacokinetics studies, G7P greatly improved the maximum plasma level and bioavailability of its corresponding genistein in vivo. This study aimed to scale the bioconversion process up from 5-L fermenter to 50-L fermenter for the production G7P, and developing a feasible and promising process for recovering G7P from fermentation broth. At first step, we reexamed the culture medium for production G7P in 5-L fermentation tank. And the results showed that the fed-batch fermentation process can achieve the best G7P conversion efficiency and production yield, with 35g genistein could be converted to G7P in 48 hours during fermentation process. Bioconversion process scale up from 5-L to 50-L can convert 1260 g genistein to G7P within 48 hours during fermentation process. Based on the results of this study, it was shown that G7P can increase the production yield by bioconversion process scale up. | en |
dc.description.provenance | Made available in DSpace on 2021-07-10T22:04:42Z (GMT). No. of bitstreams: 1 ntu-107-R05623012-1.pdf: 4171984 bytes, checksum: f8bc2f398a7a1e1c5161c9b4eb772aa3 (MD5) Previous issue date: 2018 | en |
dc.description.tableofcontents | 第一章、前言 1
第二章、文獻回顧 2 第一節 大豆異黃酮 2 1.類黃酮簡介 2 2.化學結構與生理活性 2 3.吸收與代謝 3 4.異黃酮於人體之口服生物可利用率 8 第二節 異黃酮之微生物轉換 15 1.類黃酮之微生物轉換 15 2.異黃酮之微生物轉換 16 第三節 前驅藥物 24 1.前驅藥物定義與介紹 24 2.磷酸酯前驅藥物 24 3.金雀異黃酮磷酸酯衍生物 25 第四節 生物工程技術 34 1. 生物工程 34 2. 發酵類型 34 3. 生物工程參數控制 35 4. 發酵過程中的代謝變化 36 5. 菌體濃度的影響及其控制 37 6. 營養基質的影響及其控制 38 7. 溫度的影響及其控制 39 8. pH的影響及其控制 40 9. 溶氧的影響及其控制 41 10. 泡沫的影響及其控制 42 11. 發酵終點的判斷 43 第五節 發酵液的菌體分離技術 43 1.離心 43 2.過濾 44 第三章 材料與方法 46 第一節 實驗大綱 46 第二節 材料與方法 47 1.實驗材料 47 2. 實驗方法 50 3. 分析方法 52 第四章 結果與討論 55 第一節 經由生物轉化程序生產金雀異黃酮磷酸酯 55 1. 探討發酵培養基的組成 55 2. 經由5-L 發酵槽生產金雀異黃酮磷酸酯 58 3. 經由50-L發酵槽生產金雀異黃酮磷酸酯 65 第五章 結論 71 第六章 參考文獻 72 | |
dc.language.iso | zh-TW | |
dc.title | 經由生物轉化程序生產金雀異黃酮磷酸酯之研究 | zh_TW |
dc.title | Studies on the Production of Genistein 7-O-phosphate via Bioconversion Processing | en |
dc.type | Thesis | |
dc.date.schoolyear | 106-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 胡紹揚,陳錦樹,邱淑媛,李敏雄 | |
dc.subject.keyword | Bacillus subtilis,異黃酮,生物轉化,發酵槽,金雀異黃酮磷酸酯,規模放大, | zh_TW |
dc.subject.keyword | Bacillus subtilis,isoflavone,bioconversion,bioreactor,genistein 7-O-phosphate,scale-up, | en |
dc.relation.page | 82 | |
dc.identifier.doi | 10.6342/NTU201803622 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2018-08-16 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 農業化學研究所 | zh_TW |
顯示於系所單位: | 農業化學系 |
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