請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/64909
標題: | 雙物種成長與轉換模型與其生物應用 The Two-Species Logistic Growth-Transition model and the Discussion of Its Biological Application: A Mathematical Model of Heterogeneous Cancer Growth with Autocrine Signaling Pathway |
作者: | Chih-Yuan Lee 李致遠 |
指導教授: | 陳義裕(Yih-Yuh Chen) |
關鍵字: | 非線性動力學,生物數學模型,癌症幹細胞,系統生物學,動態系統, nonlinear dynamics,biological mathematical model,cancer stem cells,system biology,dynamic system, |
出版年 : | 2012 |
學位: | 碩士 |
摘要: | 在這篇論文中,我和學長胡耿銘一起發展了一個生物數學模型。這個模型數學結構的概念是從“Transcriptome-wide noise controls lineage choice in mammalian progenitor cells.”這篇文章延伸出來的。一開始我們探究這個模型的數學特性,想找到一些有趣的數學特性。接下來我們做了許多相關的生物數學模型的文獻回顧,發現我們的模型在生物和數學的詮釋上其實可能比其他的模型都還要好。尤其是我們的模型可以很好的對應到”癌症幹細胞假說”並與實驗數據有很好的對應。於是我們便由此發展出我們自己的模型並賦予它新的生物意涵。我們也藉由對應”癌症幹細胞假說”和實驗數據時做了許多有趣的討論。我們部分的成果已經寫成文章“A Mathematical Model of Heterogeneous Cancer Growth with Autocrine Signaling Pathway.”發表在期刊 Cell Proliferations。 In this thesis, I and my senior colleague, Dr. Geng-Ming Hu, develop a biological mathematical model in which the mathematical essence is derived from the paper “Transcriptome-wide noise controls lineage choice in mammalian progenitor cells”. At first, we want to find out some interesting mathematical characteristics such as limiting cycle, but we find that it’s almost impossible to do so. Then when we research associated biological model, we find that our model may have better biological and mathematical interpretation than other models and that our model could fit well with cancer stem cell hypothesis and associated experimental data. Thus we develop our own model with its new biological essence and use it to make excellent fit with associated experimental data. Part of our research is being published in Cell Proliferations under the title “A Mathematical Model of Heterogeneous Cancer Growth with Autocrine Signaling Pathway.” |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/64909 |
全文授權: | 有償授權 |
顯示於系所單位: | 物理學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-101-1.pdf 目前未授權公開取用 | 963.82 kB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。