請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/62924
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 蘇慧敏 | |
dc.contributor.author | Kun Han | en |
dc.contributor.author | 韓琨 | zh_TW |
dc.date.accessioned | 2021-06-16T16:15:07Z | - |
dc.date.available | 2013-03-04 | |
dc.date.copyright | 2013-03-04 | |
dc.date.issued | 2013 | |
dc.date.submitted | 2013-02-06 | |
dc.identifier.citation | Beato M, Herrlich P, Schutz G (1995) Steroid hormone receptors: many actors in search of a plot. Cell 83:851-857.
Biernaskie J, Corbett D (2001) Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury. The Journal of Neuroscience 21:5272-5280. Bollag W, Holdener EE (1992) Retinoids in cancer prevention and therapy. Annals of Oncology 3:513-526. Bonnet E, Touyarot K, Alfos S, Pallet V, Higueret P, Abrous DN (2008) Retinoic acid restores adult hippocampal neurogenesis and reverses spatial memory deficit in vitamin A deprived rats. PloS One 3:e3487. Bremner JD, McCaffery P (2008) The neurobiology of retinoic acid in affective disorders. Progress in Neuro-Psychopharmacology & Biological Psychiatry 32:315-331. Brusco J, Dall'Oglio A, Rocha LB, Rossi MA, Moreira JE, Rasia-Filho AA (2010) Descriptive findings on the morphology of dendritic spines in the rat medial amygdala. Neuroscience Letters 483:152-156. Calderon F, Kim HY (2004) Docosahexaenoic acid promotes neurite growth in hippocampal neurons. Journal of Neurochemistry 90:979-988. Calderon F, Kim HY (2007) Role of RXR in neurite outgrowth induced by docosahexaenoic acid. Prostaglandins, Leukotrienes, and Essential Fatty Acids 77:227-232. Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, Kim HY (2009) Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. Journal of Neurochemistry 111:510-521. Caygill CP, Charlett A, Hill MJ (1996) Fat, fish, fish oil and cancer. British Journal of Cancer 74:159-164. Chambon P (1995) The molecular and genetic dissection of the retinoid signaling pathway. Recent Progress in Hormone Research 50:317-332. Chambon P (1996) A decade of molecular biology of retinoic acid receptors. FASEB Journal 10:940-954. Chen N, Napoli JL (2008) All-trans-retinoic acid stimulates translation and induces spine formation in hippocampal neurons through a membrane-associated RARalpha. FASEB Journal 22:236-245. Christie VB, Maltman DJ, Henderson AP, Whiting A, Marder TB, Lako M, Przyborski SA (2010) Retinoid supplementation of differentiating human neural progenitors and embryonic stem cells leads to enhanced neurogenesis in vitro. Journal of Neuroscience Methods 193:239-245. Clarke N, Germain P, Altucci L, Gronemeyer H (2004) Retinoids: potential in cancer prevention and therapy. Expert Reviews in Molecular Medicine 6:1-23. Dagai L, Peri-Naor R, Birk RZ (2009) Docosahexaenoic acid significantly stimulates immediate early response genes and neurite outgrowth. Neurochemical Research 34:867-875. de Urquiza AM, Liu S, Sjoberg M, Zetterstrom RH, Griffiths W, Sjovall J, Perlmann T (2000) Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 290:2140-2144. Decsi T, Campoy C, Koletzko B (2005) Effect of N-3 polyunsaturated fatty acid supplementation in pregnancy: the Nuheal trial. Advances in Experimental Medicine and Biology 569:109-113. Durston AJ, Timmermans JP, Hage WJ, Hendriks HF, de Vries NJ, Heideveld M, Nieuwkoop PD (1989) Retinoic acid causes an anteroposterior transformation in the developing central nervous system. Nature 340:140-144. Dyall SC, Michael GJ, Michael-Titus AT (2010) Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. Journal of Neuroscience Research 88:2091-2102. Erceg S, Lainez S, Ronaghi M, Stojkovic P, Perez-Arago MA, Moreno-Manzano V, Moreno-Palanques R, Planells-Cases R, Stojkovic M (2008) Differentiation of human embryonic stem cells to regional specific neural precursors in chemically defined medium conditions. PloS One 3:e2122. Eskild W, Hansson V, Blomhoff R (1994) Vitamin A functions in the reproductive organs. Vitamin A in Health and Disease 531-559. Giguere V, Ong ES, Segui P, Evans RM (1987) Identification of a receptor for the morphogen retinoic acid. Nature 330:624-629. Green KN, Martinez-Coria H, Khashwji H, Hall EB, Yurko-Mauro KA, Ellis L, LaFerla FM (2007) Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. The Journal of Neuroscience 27:4385-4395. Green P, Glozman S, Kamensky B, Yavin E (1999) Developmental changes in rat brain membrane lipids and fatty acids. The preferential prenatal accumulation of docosahexaenoic acid. Journal of Lipid Research 40:960-966. Haggarty P, Ashton J, Joynson M, Abramovich DR, Page K (1999) Effect of maternal polyunsaturated fatty acid concentration on transport by the human placenta. Biology of the Neonate 75:350-359. Harris KM, Jensen FE, Tsao B (1992) Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation. The Journal of Neuroscience 12:2685-2705. He C, Qu X, Cui L, Wang J, Kang JX (2009) Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid. Proceedings of the National Academy of Sciences of the United States of America 106:11370-11375. Horrocks LA, Yeo YK (1999) Health benefits of docosahexaenoic acid (DHA). Pharmacological Research 40:211-225. Hsu D (2007) The dentate gyrus as a filter or gate: a look back and a look ahead. Progress in Brain Research 163:601-613. Innis SM (2007) Dietary (n-3) fatty acids and brain development. The Journal of Nutrition 137:855-859. Jacobs S, Lie DC, DeCicco KL, Shi Y, DeLuca LM, Gage FH, Evans RM (2006) Retinoic acid is required early during adult neurogenesis in the dentate gyrus. Proceedings of the National Academy of Sciences of the United States of America 103:3902-3907. Jones BB, Ohno CK, Allenby G, Boffa MB, Levin AA, Grippo JF, Petkovich M (1995) New retinoid X receptor subtypes in zebra fish (Danio rerio) differentially modulate transcription and do not bind 9-cis retinoic acid. Molecular and Cellular Biology 15:5226-5234. Juraska JM (1990) Gender differences in the dendritic tree of granule neurons in the hippocampal dentate gyrus of weaning age rats. Brain Research Developmental Brain Research 53:291-294. Kavraal S, Oncu SK, Bitiktas S, Artis AS, Dolu N, Gunes T, Suer C (2012) Maternal intake of Omega-3 essential fatty acids improves long term potentiation in the dentate gyrus and Morris water maze performance in rats. Brain Research 1482:32-39. Krezel W, Kastner P, Chambon P (1999) Differential expression of retinoid receptors in the adult mouse central nervous system. Neuroscience 89:1291-1300. Lengqvist J, Mata De Urquiza A, Bergman AC, Willson TM, Sjovall J, Perlmann T, Griffiths WJ (2004) Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain. Molecular & Cellular Proteomics 3:692-703. Lerner AJ, Gustaw-Rothenberg K, Smyth S, Casadesus G (2012) Retinoids for treatment of Alzheimer's disease. BioFactors 38:84-89. Lin Y, Jones BW, Liu A, Tucker JF, Rapp K, Luo L, Baehr W, Bernstein PS, Watt CB, Yang JH, Shaw MV, Marc RE (2012) Retinoid receptors trigger neuritogenesis in retinal degenerations. FASEB Journal 26:81-92. Liu Y, Kagechika H, Ishikawa J, Hirano H, Matsukuma S, Tanaka K, Nakamura S (2008) Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons. Journal of Neurochemistry 106:1104-1116. Ma D, Zhang M, Larsen CP, Xu F, Hua W, Yamashima T, Mao Y, Zhou L (2010) DHA promotes the neuronal differentiation of rat neural stem cells transfected with GPR40 gene. Brain Research 1330:1-8. Maden M (2002) Retinoid signalling in the development of the central nervous system. Nature reviews Neuroscience 3:843-853. Maden M (2007) Retinoic acid in the development, regeneration and maintenance of the nervous system. Nature Reviews Neuroscience 8:755-765. Mangelsdorf DJ, Borgmeyer U, Heyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A, Evans RM (1992) Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes & Development 6:329-344. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM (1995) The nuclear receptor superfamily: the second decade. Cell 83:835-839. Martinez M (1991) Developmental profiles of polyunsaturated fatty acids in the brain of normal infants and patients with peroxisomal diseases: severe deficiency of docosahexaenoic acid in Zellweger's and pseudo-Zellweger's syndromes. World Review of Nutrition and Dietetics 66:87-102. Martinez M (1992) Tissue levels of polyunsaturated fatty acids during early human development. The Journal of Pediatrics 120:S129-138. McCaffery P, Drager UC (2000) Regulation of retinoic acid signaling in the embryonic nervous system: a master differentiation factor. Cytokine & Growth Factor Reviews 11:233-249. McCaffery PJ, Adams J, Maden M, Rosa-Molinar E (2003) Too much of a good thing: retinoic acid as an endogenous regulator of neural differentiation and exogenous teratogen. The European Journal of Neuroscience 18:457-472. Misner DL, Jacobs S, Shimizu Y, de Urquiza AM, Solomin L, Perlmann T, De Luca LM, Stevens CF, Evans RM (2001) Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America 98:11714-11719. Morris RG (2006) Elements of a neurobiological theory of hippocampal function: the role of synaptic plasticity, synaptic tagging and schemas. The European Journal of Neuroscience 23:2829-2846. O'Connor DL, Hall R, Adamkin D, Auestad N, Castillo M, Connor WE, Connor SL, Fitzgerald K, Groh-Wargo S, Hartmann EE, Jacobs J, Janowsky J, Lucas A, Margeson D, Mena P, Neuringer M, Nesin M, Singer L, Stephenson T, Szabo J, Zemon V, Ross Preterm Lipid S (2001) Growth and development in preterm infants fed long-chain polyunsaturated fatty acids: a prospective, randomized controlled trial. Pediatrics 108:359-371. Pierani A, Brenner-Morton S, Chiang C, Jessell TM (1999) A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Cell 97:903-915. Rahimi O, Claiborne BJ (2007) Morphological development and maturation of granule neuron dendrites in the rat dentate gyrus. Progress in Brain Research 163:167-181. Rando RR (1994) Retinoid isomerization reactions in the visual system. pp 503-529 New York: Marcel Dekker, Inc. Rapoport SI (2001) In vivo fatty acid incorporation into brain phosholipids in relation to plasma availability, signal transduction and membrane remodeling. Journal of Molecular Neuroscience 16:243-261; discussion 279-284. Riediger ND, Azordegan N, Harris-Janz S, Ma DW, Suh M, Moghadasian MH (2009) 'Designer oils' low in n-6:n-3 fatty acid ratio beneficially modifies cardiovascular risks in mice. European Journal of Nutrition 48:307-314. Rihn LL, Claiborne BJ (1990) Dendritic growth and regression in rat dentate granule cells during late postnatal development. Brain Research Developmental Brain Research 54:115-124. Robson LG, Dyall S, Sidloff D, Michael-Titus AT (2010) Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals. Neurobiology of Aging 31:678-687. Rosenthal D, Lancillotti F, Darwiche N, Sinha R, De Luca LM (1994) Regulation of epithelial differentiation by retinoids. Vitamin A in Health and Disease 135-188. Ross A, Hammerling U (1994) Retinoids and the immune system. The Retinoids: Biology, Chemistry and Medicine, ed 2:521-543. Rotstein NP, Politi LE, German OL, Girotti R (2003) Protective effect of docosahexaenoic acid on oxidative stress-induced apoptosis of retina photoreceptors. Investigative Ophthalmology & Visual Science 44:2252-2259. Ruyle M, Connor WE, Anderson GJ, Lowensohn RI (1990) Placental transfer of essential fatty acids in humans: venous-arterial difference for docosahexaenoic acid in fetal umbilical erythrocytes. Proceedings of the National Academy of Sciences of the United States of America 87:7902-7906. Sakamoto T, Cansev M, Wurtman RJ (2007) Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus. Brain Research 1182:50-59. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805-809. Schwellenbach LJ, Olson KL, McConnell KJ, Stolcpart RS, Nash JD, Merenich JA, Clinical Pharmacy Cardiac Risk Service Study G (2006) The triglyceride-lowering effects of a modest dose of docosahexaenoic acid alone versus in combination with low dose eicosapentaenoic acid in patients with coronary artery disease and elevated triglycerides. Journal of the American College of Nutrition 25:480-485. Sinclair AJ, Crawford MA (1972) The accumulation of arachidonate and docosahexaenoate in the developing rat brain. Journal of Neurochemistry 19:1753-1758. Sporn MB, Roberts AB, Goodman DWS (1994) The retinoids: biology, chemistry, and medicine: Raven Press New York:. Stillwell W, Wassall SR (2003) Docosahexaenoic acid: membrane properties of a unique fatty acid. Chemistry and Physics of Lipids 126:1-27. Su HM (2010) Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. The Journal of Nutritional Biochemistry 21:364-373. Uauy R, Calderon F, Mena P (2001) Essential fatty acids in somatic growth and brain development. World Review of Nutrition and Dietetics 89:134-160. Wainwright PE, Huang YS, Coscina DV, Levesque S, McCutcheon D (1994) Brain and behavioral effects of dietary n-3 deficiency in mice: a three generational study. Developmental Psychobiology 27:467-487. Wei W, Nguyen LN, Kessels HW, Hagiwara H, Sisodia S, Malinow R (2010) Amyloid beta from axons and dendrites reduces local spine number and plasticity. Nature Neuroscience 13:190-196. Weiss K, Mihaly J, Liebisch G, Marosvolgyi T, Schmitz G, Decsi T, Ruhl R (2011) Effect of synthetic ligands of PPAR alpha, beta/delta, gamma, RAR, RXR and LXR on the fatty acid composition of phospholipids in mice. Lipids 46:1013-1020. Wietrzych-Schindler M, Szyszka-Niagolov M, Ohta K, Endo Y, Perez E, de Lera AR, Chambon P, Krezel W (2011) Retinoid x receptor gamma is implicated in docosahexaenoic acid modulation of despair behaviors and working memory in mice. Biological Psychiatry 69:788-794. Wilkinson P, Leach C, Ah-Sing EE, Hussain N, Miller GJ, Millward DJ, Griffin BA (2005) Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype. Atherosclerosis 181:115-124. Wu A, Ying Z, Gomez-Pinilla F (2008) Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neuroscience 155:751-759. Wu H, Ichikawa S, Tani C, Zhu B, Tada M, Shimoishi Y, Murata Y, Nakamura Y (2009) Docosahexaenoic acid induces ERK1/2 activation and neuritogenesis via intracellular reactive oxygen species production in human neuroblastoma SH-SY5Y cells. Biochimica et Biophysica Acta 1791:8-16. Zhang X, Chen K, Chen J, Liu YX, Qu P, Li TY (2011) Effect of marginal vitamin A deficiency during pregnancy on retinoic acid receptors and N-methyl-D-aspartate receptor expression in the offspring of rats. The Journal of Nutritional Biochemistry 22:1112-1120. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/62924 | - |
dc.description.abstract | 二十二碳六烯酸 (docosahexaenoic acid, DHA) 與維生素A均為必需營養素,皆在大腦發育及維持神經正常生理功能中扮演重要的角色。DHA主要是在大腦發育時期 (胚胎期與泌乳期) 快速在大腦累積。另有文獻指出DHA亦為維生素A受體的配體之一,可藉之促進神經的生長。本論文探討大鼠大腦發育時期海馬迴DHA的變化及海馬迴中齒狀迴顆粒狀細胞 (dentate granule cells) 形態改變,並探討DHA含量的不同或維生素A缺乏是否會影響其細胞成長及DHA是否可恢復維生素A缺乏對其形態之影響。於母鼠懷孕與泌乳期間,餵食含玉米油之正常飼料或維生素A缺乏之飼料以及補充富含DHA之魚油,並於其子代出生後第零天 (P0)、第七天 (P7)、第十四天 (P14) 以及第二十一天 (P21) 犧牲,以氣相層析儀分析海馬迴脂肪酸成分,Golgi-Cox染色法觀察齒狀迴顆粒狀細胞之形態。結果發現大鼠大腦發育時期腦中DHA含量隨出生天數增加而上升,齒狀迴顆粒狀細胞之樹突總長度、分岔點的數量、末端點的數量、分節的數量、樹突分枝層級、分節數量皆隨出生天數增加而上升,但唯獨維生素A缺乏組在P21時上升的趨勢漸緩。母鼠補充魚油可增加子代在大腦發育時期海馬迴DHA含量,也顯著增加P7和P14大鼠齒狀迴顆粒狀細胞樹突總長度。齒狀迴顆粒狀細胞樹突棘與蘑菇形樹突棘之密度樹突總長度、末端點的數量、分節的數量在餵食維生素A缺乏組較正常組於P21時顯著下降,而魚油補充可恢復其生長。推測DHA可增進並恢復維生素A缺乏對於發育大鼠齒狀迴顆粒狀細胞成長之影響。 | zh_TW |
dc.description.abstract | Brain docosahexaenoic acid (DHA, 22:6n-3) accumulates rapidly during brain development and is essential for normal neurological function. Vitamin A including retinoid and their derivatives has similar effects to n-3 fatty acids on neurological function. DHA is one of ligands of retinoic receptors which signaling is essential for neurite outgrowth. The aim of this study was to examine the changes of DHA levels and morphology of dentate granule cells during the brain development and the effect of brain DHA levels on neuronal maturation. We also evaluated the effects of vitamin A deficiency on maturation of dentate granule cells and whether it could be recovered by DHA. Rats were exposed to corn oil-based n-3 fatty acid-control or vitamin A-deficient diets or the two diets supplemented with DHA-enriched fish oil from in utero via maternal intake. The pups were sacrificed at the age of 0, 7, 14 and 21 days old. The fatty acid composition in hippocampus and morphology of dentate granule cells were analyzed by gas chromatography and Golgi-Cox staining, respectively. Levels of DHA in brain regions were increased gradually from age of 0 to 21 days old. The morphology of dentate granule cells including total dendritic length, highest order, number of bifurcation nodes, number of terminal endings, and number of segments were increased from 0- to 21-day-old. The DHA levels were significantly higher in rats exposed to fish oil supplementation and DHA enhanced the total dendritic length of dentate granule cells in rats at age of 7-14 day old exposed to control or vitamin A-deficient diets. The total spine density, mushroom type spine density, total dendritic length, highest order, number of bifurcation nodes, number of terminal endings, and number of segments were significantly decreased in 21-day-old rats exposed to vitamin A-deficient diet and the effects was recovered back with fish oil supplementation. This study suggests that DHA and vitamin A are important for the maturation of dentate granule cells and DHA may play a role in retinoid signaling in neuronal development. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T16:15:07Z (GMT). No. of bitstreams: 1 ntu-102-R98441013-1.pdf: 6251685 bytes, checksum: 6f99054161f5a6dfcb0628834f0fadfa (MD5) Previous issue date: 2013 | en |
dc.description.tableofcontents | 中文摘要……… I
Abstract……… II 目錄…………. IV 第壹章、文獻回顧 1 一、二十二碳六烯酸 1 二、DHA與神經系統 2 三、維生素A 3 四、維生素A與神經系統 4 五、DHA與維生素A的關聯性 5 第貳章、研究目標 7 第參章、材料與方法 8 一、實驗動物與實驗設計 8 二、實驗動物飼料 9 三、脂肪酸檢測分析 10 四、氣相層析儀分析 11 五、心臟灌流 12 六、Golgi-Cox染色法 13 七、海馬迴顆粒狀細胞樹突形態之分析 15 八、統計分析 15 第肆章、結果 16 一、DHA及維生素A缺乏對母鼠與幼鼠體重及腦重的影響 16 二、DHA及維生素A缺乏對鼠腦脂肪酸成分之影響 17 三、DHA及維生素A缺乏對幼鼠齒狀迴顆粒狀細胞樹突形態之影響 18 1.樹突分枝情形之分析 19 2.樹突分枝分布情形與複雜度 20 3.樹突棘與蘑菇形樹突棘之密度分析 22 第伍章、討論 25 一、實驗動物之建立 25 二、DHA及維生素A缺乏對母鼠食量、母鼠與幼鼠體重及腦重之關聯性 26 三、DHA及維生素A缺乏對鼠腦中的DHA與DPA變化之關聯性 27 四、以Golgi-Cox染色法觀測幼鼠神經形態之準確性 28 五、DHA及維生素A缺乏對幼鼠齒狀迴顆粒狀細胞樹突形態之影響 29 1. DHA及維生素A缺乏對樹突分枝情形之影響 29 2. DHA及維生素A缺乏對樹突分枝分布情形與複雜度之影響 31 3. DHA及維生素A缺乏對總樹突棘與蘑菇形樹突棘密度之影響 32 4. DHA與維生素A缺乏影響齒狀迴顆粒狀細胞成長之可能機制 33 第陸章、總結 35 第柒章、表目錄 36 Table 1 各組母鼠產下子代的數量表 36 Table 2 控制組飼料及維生素A缺乏之飼料之熱量表 36 Table 3 控制組飼料與維生素A缺乏之飼料之成分 37 Table 4 控制組飼料、維生素A缺乏之飼料、葵花油及魚油之脂肪酸成分 38 Table 5 母鼠於懷孕與泌乳期攝取正常或維生素A缺乏之飼料下補充魚油與否之海馬迴脂肪酸成分 39 Table 6 幼鼠於大腦發育期經由母鼠攝取正常飼料之海馬迴脂肪酸成分 40 Table 7 幼鼠於大腦發育期經由母鼠攝取正常飼料及補充魚油之海馬迴脂肪酸成分 41 Table 8 幼鼠於大腦發育期經由母鼠攝取維生素A缺乏之飼料之海馬迴脂肪酸成分…… 42 Table 9 幼鼠於大腦發育期經由母鼠攝取維生素A缺乏之飼料及補充魚油之海馬迴脂肪酸成分 43 Table 10 DHA與VAD於P0至P21對齒狀迴顆粒狀細胞之各項形態參數之影響…… 44 第捌章、圖目錄 45 Fig. 1 各組子代實驗分配圖 45 Fig. 2 實驗設計 46 Fig. 3 母鼠懷孕期與泌乳期之食量紀錄 47 Fig. 4 母鼠與幼鼠之體重與腦重變化 48 Fig. 5 母鼠與幼鼠海馬迴的DHA與DPA含量 49 Fig. 6 幼鼠齒狀迴顆粒狀細胞樹突形態示意圖 50 Fig. 7 幼鼠在P0、P7、P14及P21時於齒狀迴顆粒狀細胞之樹突總長度 51 Fig. 8 幼鼠在P0、P7、P14及P21時於齒狀迴顆粒狀細胞之樹突最高層級 52 Fig. 9 幼鼠在P0、P7、P14及P21時於齒狀迴顆粒狀細胞之樹突分岔點的數量…… 53 Fig. 10 幼鼠在P0、P7、P14及P21時於齒狀迴顆粒狀細胞之樹突末端點的數量………… 54 Fig. 11 幼鼠在P0、P7、P14及P21時於齒狀迴顆粒狀細胞之樹突分節的數量………… 55 Fig. 12 各組在四種時間點下的齒狀迴顆粒狀細胞染色圖及其描繪影像 56 Fig. 13 幼鼠在P0、P7、P14及P21時於齒狀迴顆粒狀細胞的樹突分枝層級與分節數量之關係 57 Fig. 14 幼鼠在P0、P7、P14及P21時於齒狀迴顆粒狀細胞之Sholl analysis 58 Fig. 15 幼鼠在P14及P21時於齒狀迴顆粒狀細胞之總樹突棘密度以及蘑菇形樹突棘密度 59 Fig. 16 各組在P14及P21的齒狀迴顆粒狀細胞之樹突分節染色圖 60 第玖章、參考文獻 61 | |
dc.language.iso | zh-TW | |
dc.title | 探討腦部二十二碳六烯酸在維生素A缺乏下對發育大鼠齒狀迴顆粒狀細胞成長之影響 | zh_TW |
dc.title | Effects of brain docosahexaenoic acid on neuronal maturation in developing dentate granule cells in vitamin A-deficient rats | en |
dc.type | Thesis | |
dc.date.schoolyear | 101-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 蔡元奮,呂紹俊,李立仁 | |
dc.subject.keyword | 二十二碳六烯酸,維生素A,齒狀迴顆粒狀細胞, | zh_TW |
dc.subject.keyword | docosahexaenoic acid,vitamin A,dentate granule cell, | en |
dc.relation.page | 67 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2013-02-06 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 生理學研究所 | zh_TW |
顯示於系所單位: | 生理學科所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-102-1.pdf 目前未授權公開取用 | 6.11 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。