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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳小梨(Show-Li Chen) | |
dc.contributor.author | Chao-Hsin Chang | en |
dc.contributor.author | 張釗昕 | zh_TW |
dc.date.accessioned | 2021-06-15T13:46:14Z | - |
dc.date.available | 2022-08-31 | |
dc.date.copyright | 2020-09-04 | |
dc.date.issued | 2020 | |
dc.date.submitted | 2020-08-09 | |
dc.identifier.citation | Ajuh, P., B. Kuster, K. Panov, J. C. Zomerdijk, M. Mann, and A. I. Lamond. 2000. 'Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry', EMBO J, 19: 6569-81. Altman, J., and S. A. Bayer. 1990. 'Mosaic organization of the hippocampal neuroepithelium and the multiple germinal sources of dentate granule cells', J Comp Neurol, 301: 325-42. Altman, J., and G. D. Das. 1965. 'Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats', J Comp Neurol, 124: 319-35. Alvarez-Buylla, A., and J. M. Garcia-Verdugo. 2002. 'Neurogenesis in adult subventricular zone', J Neurosci, 22: 629-34. Beck, B. D., S. J. Park, Y. J. Lee, Y. Roman, R. A. Hromas, and S. H. Lee. 2008. 'Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair', J Biol Chem, 283: 9023-30. Bengoa-Vergniory, N., and R. M. Kypta. 2015. 'Canonical and noncanonical Wnt signaling in neural stem/progenitor cells', Cell Mol Life Sci, 72: 4157-72. Bird, C. M., and N. Burgess. 2008. 'The hippocampus and memory: insights from spatial processing', Nat Rev Neurosci, 9: 182-94. Blalock, E. M., J. W. Geddes, K. C. Chen, N. M. Porter, W. R. Markesbery, and P. W. Landfield. 2004. 'Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses', Proc Natl Acad Sci U S A, 101: 2173-8. Bonafina, Antonela, Gustavo Paratcha, and Fernanda Ledda. 2020. 'Deciphering New Players in the Neurogenic Adult Hippocampal Niche', Frontiers in Cell and Developmental Biology, 8. Bondi, M. W., E. C. Edmonds, and D. P. Salmon. 2017. 'Alzheimer's Disease: Past, Present, and Future', J Int Neuropsychol Soc, 23: 818-31. Brandt, M. D., S. Jessberger, B. Steiner, G. Kronenberg, K. Reuter, A. Bick-Sander, W. von der Behrens, and G. Kempermann. 2003. 'Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice', Mol Cell Neurosci, 24: 603-13. Brembeck, F. H., M. Rosario, and W. Birchmeier. 2006. 'Balancing cell adhesion and Wnt signaling, the key role of beta-catenin', Curr Opin Genet Dev, 16: 51-9. Broadbent, N. J., L. R. Squire, and R. E. Clark. 2004. 'Spatial memory, recognition memory, and the hippocampus', Proc Natl Acad Sci U S A, 101: 14515-20. Cassé, Frédéric, Kevin Richetin, and Nicolas Toni. 2018. 'Astrocytes’ Contribution to Adult Neurogenesis in Physiology and Alzheimer’s Disease', Frontiers in Cellular Neuroscience, 12. Chan, S. P., and S. C. Cheng. 2005. 'The Prp19-associated complex is required for specifying interactions of U5 and U6 with pre-mRNA during spliceosome activation', J Biol Chem, 280: 31190-9. Chan, S. P., D. I. Kao, W. Y. Tsai, and S. C. Cheng. 2003. 'The Prp19p-associated complex in spliceosome activation', Science, 302: 279-82. Chen, P. H., C. I. Lee, Y. T. Weng, W. Y. Tarn, Y. P. Tsao, P. C. Kuo, P. H. Hsu, C. W. Huang, C. S. Huang, H. H. Lee, J. T. Wu, and S. L. Chen. 2013. 'BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing', RNA, 19: 208-18. Cheshier, S. H., S. J. Morrison, X. Liao, and I. L. Weissman. 1999. 'In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells', Proc Natl Acad Sci U S A, 96: 3120-5. Chou, M. H., Y. C. Hsieh, C. W. Huang, P. H. Chen, S. P. Chan, Y. P. Tsao, H. H. Lee, J. T. Wu, and S. L. Chen. 2015. 'BCAS2 Regulates Delta-Notch Signaling Activity through Delta Pre-mRNA Splicing in Drosophila Wing Development', PLoS One, 10: e0130706. Cisternas, P., and N. C. Inestrosa. 2017. 'Brain glucose metabolism: Role of Wnt signaling in the metabolic impairment in Alzheimer's disease', Neurosci Biobehav Rev, 80: 316-28. Crews, L., A. Adame, C. Patrick, A. Delaney, E. Pham, E. Rockenstein, L. Hansen, and E. Masliah. 2010. 'Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis', J Neurosci, 30: 12252-62. De Ferrari, G. V., and R. T. Moon. 2006. 'The ups and downs of Wnt signaling in prevalent neurological disorders', Oncogene, 25: 7545-53. Del Rio, J. A., B. Heimrich, V. Borrell, E. Forster, A. Drakew, S. Alcantara, K. Nakajima, T. Miyata, M. Ogawa, K. Mikoshiba, P. Derer, M. Frotscher, and E. Soriano. 1997. 'A role for Cajal-Retzius cells and reelin in the development of hippocampal connections', Nature, 385: 70-4. Deng, W., J. B. Aimone, and F. H. Gage. 2010. 'New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?', Nat Rev Neurosci, 11: 339-50. Doetsch, F., J. M. Garcia-Verdugo, and A. Alvarez-Buylla. 1999. 'Regeneration of a germinal layer in the adult mammalian brain', Proc Natl Acad Sci U S A, 96: 11619-24. Dragatsis, I., and S. Zeitlin. 2000. 'CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain', Genesis, 26: 133-5. Fiorentini, A., M. C. Rosi, C. Grossi, I. Luccarini, and F. Casamenti. 2010. 'Lithium improves hippocampal neurogenesis, neuropathology and cognitive functions in APP mutant mice', PLoS One, 5: e14382. Gage, F. H. 2000. 'Mammalian neural stem cells', Science, 287: 1433-8. Gao, X., P. Arlotta, J. D. Macklis, and J. Chen. 2007. 'Conditional knock-out of beta-catenin in postnatal-born dentate gyrus granule neurons results in dendritic malformation', J Neurosci, 27: 14317-25. Garcia, A. L., A. Udeh, K. Kalahasty, and A. S. Hackam. 2018. 'A growing field: The regulation of axonal regeneration by Wnt signaling', Neural Regen Res, 13: 43-52. Goncalves, J. T., S. T. Schafer, and F. H. Gage. 2016. 'Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior', Cell, 167: 897-914. Gotz, M., and W. B. Huttner. 2005. 'The cell biology of neurogenesis', Nat Rev Mol Cell Biol, 6: 777-88. Gould, T. D., H. Einat, K. C. O'Donnell, A. M. Picchini, R. J. Schloesser, and H. K. Manji. 2007. 'Beta-catenin overexpression in the mouse brain phenocopies lithium-sensitive behaviors', Neuropsychopharmacology, 32: 2173-83. Grote, M., E. Wolf, C. L. Will, I. Lemm, D. E. Agafonov, A. Schomburg, W. Fischle, H. Urlaub, and R. Luhrmann. 2010. 'Molecular architecture of the human Prp19/CDC5L complex', Mol Cell Biol, 30: 2105-19. Hattiangady, B., B. Shuai, J. Cai, T. Coksaygan, M. S. Rao, and A. K. Shetty. 2007. 'Increased dentate neurogenesis after grafting of glial restricted progenitors or neural stem cells in the aging hippocampus', Stem Cells, 25: 2104-17. He, X., M. Semenov, K. Tamai, and X. Zeng. 2004. 'LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way', Development, 131: 1663-77. Hofmann, J. C., J. Tegha-Dunghu, S. Drager, C. L. Will, R. Luhrmann, and O. J. Gruss. 2013. 'The Prp19 complex directly functions in mitotic spindle assembly', PLoS One, 8: e74851. Hollands, C., N. Bartolotti, and O. Lazarov. 2016. 'Alzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms', Front Neurosci, 10: 178. Hong, S., V. F. Beja-Glasser, B. M. Nfonoyim, A. Frouin, S. Li, S. Ramakrishnan, K. M. Merry, Q. Shi, A. Rosenthal, B. A. Barres, C. A. Lemere, D. J. Selkoe, and B. Stevens. 2016. 'Complement and microglia mediate early synapse loss in Alzheimer mouse models', Science, 352: 712-16. Hsieh, J. 2012. 'Orchestrating transcriptional control of adult neurogenesis', Genes Dev, 26: 1010-21. Hu, Y., W. Chen, L. Wu, L. Jiang, N. Liang, L. Tan, M. Liang, and N. Tang. 2019. 'TGF-beta1 Restores Hippocampal Synaptic Plasticity and Memory in Alzheimer Model via the PI3K/Akt/Wnt/beta-Catenin Signaling Pathway', J Mol Neurosci, 67: 142-49. Huang, C. W., Y. W. Chen, Y. R. Lin, P. H. Chen, M. H. Chou, L. J. Lee, P. Y. Wang, J. T. Wu, Y. P. Tsao, and S. L. Chen. 2016. 'Conditional Knockout of Breast Carcinoma Amplified Sequence 2 (BCAS2) in Mouse Forebrain Causes Dendritic Malformation via beta-catenin', Sci Rep, 6: 34927. Huang, M., Y. Liang, H. Chen, B. Xu, C. Chai, and P. Xing. 2018. 'The Role of Fluoxetine in Activating Wnt/beta-Catenin Signaling and Repressing beta-Amyloid Production in an Alzheimer Mouse Model', Front Aging Neurosci, 10: 164. Hui, J., J. Zhang, M. Pu, X. Zhou, L. Dong, X. Mao, G. Shi, J. Zou, J. Wu, D. Jiang, and G. Xi. 2018. 'Modulation of GSK-3beta/beta-Catenin Signaling Contributes to Learning and Memory Impairment in a Rat Model of Depression', Int J Neuropsychopharmacol, 21: 858-70. Hussaini, S. M., C. I. Choi, C. H. Cho, H. J. Kim, H. Jun, and M. H. Jang. 2014. 'Wnt signaling in neuropsychiatric disorders: ties with adult hippocampal neurogenesis and behavior', Neurosci Biobehav Rev, 47: 369-83. Inestrosa, N. C., and L. Varela-Nallar. 2015. 'Wnt signalling in neuronal differentiation and development', Cell Tissue Res, 359: 215-23. Inkster, B., T. E. Nichols, P. G. Saemann, D. P. Auer, F. Holsboer, P. Muglia, and P. M. Matthews. 2009. 'Association of GSK3beta polymorphisms with brain structural changes in major depressive disorder', Arch Gen Psychiatry, 66: 721-8. Karalay, O., K. Doberauer, K. C. Vadodaria, M. Knobloch, L. Berti, A. Miquelajauregui, M. Schwark, R. Jagasia, M. M. Taketo, V. Tarabykin, D. C. Lie, and S. Jessberger. 2011. 'Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis', Proc Natl Acad Sci U S A, 108: 5807-12. Kempermann, G., H. Song, and F. H. Gage. 2015. 'Neurogenesis in the Adult Hippocampus', Cold Spring Harb Perspect Biol, 7: a018812. Kronenberg, G., K. Reuter, B. Steiner, M. D. Brandt, S. Jessberger, M. Yamaguchi, and G. Kempermann. 2003. 'Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli', J Comp Neurol, 467: 455-63. Kuo, P. C., C. W. Huang, C. I. Lee, H. W. Chang, S. W. Hsieh, Y. P. Chung, M. S. Lee, C. S. Huang, L. P. Tsao, Y. P. Tsao, and S. L. Chen. 2015. 'BCAS2 promotes prostate cancer cells proliferation by enhancing AR mRNA transcription and protein stability', Br J Cancer, 112: 391-402. Kuo, P. C., Y. P. Tsao, H. W. Chang, P. H. Chen, C. W. Huang, S. T. Lin, Y. T. Weng, T. C. Tsai, S. Y. Shieh, and S. L. Chen. 2009. 'Breast cancer amplified sequence 2, a novel negative regulator of the p53 tumor suppressor', Cancer Res, 69: 8877-85. Kuwabara, T., J. Hsieh, A. Muotri, G. Yeo, M. Warashina, D. C. Lie, L. Moore, K. Nakashima, M. Asashima, and F. H. Gage. 2009. 'Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis', Nat Neurosci, 12: 1097-105. Lang, B., and S. Zhao. 2018. 'miR-486 functions as a tumor suppressor in esophageal cancer by targeting CDK4/BCAS2', Oncol Rep, 39: 71-80. Li, G., N. Bien-Ly, Y. Andrews-Zwilling, Q. Xu, A. Bernardo, K. Ring, B. Halabisky, C. Deng, R. W. Mahley, and Y. Huang. 2009. 'GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice', Cell Stem Cell, 5: 634-45. Li, X., M. Liu, Z. Cai, G. Wang, and X. Li. 2010. 'Regulation of glycogen synthase kinase-3 during bipolar mania treatment', Bipolar Disord, 12: 741-52. Liao, S., R. Du, L. Wang, Z. Qu, X. Cui, C. Li, F. Liu, M. Huang, J. Wang, J. Chen, M. Gao, S. Yu, Z. Tang, D. W. Li, T. Jiang, and M. Liu. 2015. 'BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination', Int J Biochem Cell Biol, 68: 78-86. Lie, D. C., S. A. Colamarino, H. J. Song, L. Desire, H. Mira, A. Consiglio, E. S. Lein, S. Jessberger, H. Lansford, A. R. Dearie, and F. H. Gage. 2005. 'Wnt signalling regulates adult hippocampal neurogenesis', Nature, 437: 1370-5. Liu, W., F. Wang, Q. Xu, J. Shi, X. Zhang, X. Lu, Z. A. Zhao, Z. Gao, H. Ma, E. Duan, F. Gao, S. Gao, Z. Yi, and L. Li. 2017. 'BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis', Nat Commun, 8: 14182. Logan, C. Y., and R. Nusse. 2004. 'The Wnt signaling pathway in development and disease', Annu Rev Cell Dev Biol, 20: 781-810. Lukashchuk, V., K. E. Lewis, I. Coldicott, A. J. Grierson, and M. Azzouz. 2016. 'AAV9-mediated central nervous system-targeted gene delivery via cisterna magna route in mice', Mol Ther Methods Clin Dev, 3: 15055. Maass, N., F. Rosel, C. Schem, J. Hitomi, W. Jonat, and K. Nagasaki. 2002. 'Amplification of the BCAS2 gene at chromosome 1p13.3-21 in human primary breast cancer', Cancer Lett, 185: 219-23. MacDonald, B. T., K. Tamai, and X. He. 2009. 'Wnt/beta-catenin signaling: components, mechanisms, and diseases', Dev Cell, 17: 9-26. Machhi, J., A. Sinha, P. Patel, A. M. Kanhed, P. Upadhyay, A. Tripathi, Z. S. Parikh, R. Chruvattil, P. P. Pillai, S. Gupta, K. Patel, R. Giridhar, and M. R. Yadav. 2016. 'Neuroprotective Potential of Novel Multi-Targeted Isoalloxazine Derivatives in Rodent Models of Alzheimer's Disease Through Activation of Canonical Wnt/beta-Catenin Signalling Pathway', Neurotox Res, 29: 495-513. Machon, O., M. Backman, O. Machonova, Z. Kozmik, T. Vacik, L. Andersen, and S. Krauss. 2007. 'A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus', Dev Biol, 311: 223-37. Mahajan, K. N., and B. S. Mitchell. 2003. 'Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase', Proc Natl Acad Sci U S A, 100: 10746-51. Mao, Y., X. Ge, C. L. Frank, J. M. Madison, A. N. Koehler, M. K. Doud, C. Tassa, E. M. Berry, T. Soda, K. K. Singh, T. Biechele, T. L. Petryshen, R. T. Moon, S. J. Haggarty, and L. H. Tsai. 2009. 'Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling', Cell, 136: 1017-31. Marechal, A., J. M. Li, X. Y. Ji, C. S. Wu, S. A. Yazinski, H. D. Nguyen, S. Liu, A. E. Jimenez, J. Jin, and L. Zou. 2014. 'PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry', Mol Cell, 53: 235-46. Margolin, G., P. P. Khil, J. Kim, M. A. Bellani, and R. D. Camerini-Otero. 2014. 'Integrated transcriptome analysis of mouse spermatogenesis', BMC Genomics, 15: 39. Marinaro, C., M. Pannese, F. Weinandy, A. Sessa, A. Bergamaschi, M. M. Taketo, V. Broccoli, G. Comi, M. Gotz, G. Martino, and L. Muzio. 2012. 'Wnt signaling has opposing roles in the developing and the adult brain that are modulated by Hipk1', Cereb Cortex, 22: 2415-27. Masiulis, I., S. Yun, and A. J. Eisch. 2011. 'The interesting interplay between interneurons and adult hippocampal neurogenesis', Mol Neurobiol, 44: 287-302. Mishra, A., S. Singh, V. Tiwari, Parul, and S. Shukla. 2019. 'Dopamine D1 receptor activation improves adult hippocampal neurogenesis and exerts anxiolytic and antidepressant-like effect via activation of Wnt/beta-catenin pathways in rat model of Parkinson's disease', Neurochem Int, 122: 170-86. Munji, R. N., Y. Choe, G. Li, J. A. Siegenthaler, and S. J. Pleasure. 2011. 'Wnt signaling regulates neuronal differentiation of cortical intermediate progenitors', J Neurosci, 31: 1676-87. Nagasaki, K., N. Maass, T. Manabe, H. Hanzawa, T. Tsukada, K. Kikuchi, and K. Yamaguchi. 1999. 'Identification of a novel gene, DAM1, amplified at chromosome 1p13.3-21 region in human breast cancer cell lines', Cancer Lett, 140: 219-26. Neubauer, G., A. King, J. Rappsilber, C. Calvio, M. Watson, P. Ajuh, J. Sleeman, A. Lamond, and M. Mann. 1998. 'Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex', Nat Genet, 20: 46-50. Ohi, M. D., C. W. Vander Kooi, J. A. Rosenberg, L. Ren, J. P. Hirsch, W. J. Chazin, T. Walz, and K. L. Gould. 2005. 'Structural and functional analysis of essential pre-mRNA splicing factor Prp19p', Mol Cell Biol, 25: 451-60. Orford, K. W., and D. T. Scadden. 2008. 'Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation', Nat Rev Genet, 9: 115-28. Parma, P., O. Radi, V. Vidal, M. C. Chaboissier, E. Dellambra, S. Valentini, L. Guerra, A. Schedl, and G. Camerino. 2006. 'R-spondin1 is essential in sex determination, skin differentiation and malignancy', Nat Genet, 38: 1304-9. Pleasure, S. J., A. E. Collins, and D. H. Lowenstein. 2000. 'Unique expression patterns of cell fate molecules delineate sequential stages of dentate gyrus development', J Neurosci, 20: 6095-105. Qi, C., Y. T. Zhu, J. Chang, A. V. Yeldandi, M. S. Rao, and Y. J. Zhu. 2005. 'Potentiation of estrogen receptor transcriptional activity by breast cancer amplified sequence 2', Biochem Biophys Res Commun, 328: 393-8. Regensburger, M., I. Prots, D. Reimer, S. Brachs, S. Loskarn, D. C. Lie, D. Mielenz, and B. Winner. 2018. 'Impact of Swiprosin-1/Efhd2 on Adult Hippocampal Neurogenesis', Stem Cell Reports, 10: 347-55. Reitz, C., and R. Mayeux. 2014. 'Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers', Biochem Pharmacol, 88: 640-51. Rickmann, M., D. G. Amaral, and W. M. Cowan. 1987. 'Organization of radial glial cells during the development of the rat dentate gyrus', J Comp Neurol, 264: 449-79. Rolando, C., and V. Taylor. 2014. 'Neural stem cell of the hippocampus: development, physiology regulation, and dysfunction in disease', Curr Top Dev Biol, 107: 183-206. Samaranch, L., A. Perez-Canamas, B. Soto-Huelin, V. Sudhakar, J. Jurado-Arjona, P. Hadaczek, J. Avila, J. R. Bringas, J. Casas, H. Chen, X. He, E. H. Schuchman, S. H. Cheng, J. Forsayeth, K. S. Bankiewicz, and M. D. Ledesma. 2019. 'Adeno-associated viral vector serotype 9-based gene therapy for Niemann-Pick disease type A', Sci Transl Med, 11. Schneider, R., B. Koop, F. Schroter, J. Cline, J. Ingwersen, C. Berndt, H. P. Hartung, O. Aktas, and T. Prozorovski. 2016. 'Activation of Wnt signaling promotes hippocampal neurogenesis in experimental autoimmune encephalomyelitis', Mol Neurodegener, 11: 53. Sengupta, D., D. K. Bhargava, A. Dixit, B. S. Sahoo, S. Biswas, G. Biswas, and S. K. Mishra. 2014. 'ERRbeta signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells', Br J Cancer, 110: 2144-58. Seri, B., J. M. Garcia-Verdugo, B. S. McEwen, and A. Alvarez-Buylla. 2001. 'Astrocytes give rise to new neurons in the adult mammalian hippocampus', J Neurosci, 21: 7153-60. Simons, B. D., and H. Clevers. 2011. 'Strategies for homeostatic stem cell self-renewal in adult tissues', Cell, 145: 851-62. Smith, K., and M. V. Semenov. 2019. 'The impact of age on number and distribution of proliferating cells in subgranular zone in adult mouse brain', IBRO Rep, 6: 18-30. Song, H., C. F. Stevens, and F. H. Gage. 2002. 'Astroglia induce neurogenesis from adult neural stem cells', Nature, 417: 39-44. Song, J., J. Sun, J. Moss, Z. Wen, G. J. Sun, D. Hsu, C. Zhong, H. Davoudi, K. M. Christian, N. Toni, G. L. Ming, and H. Song. 2013. 'Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus', Nat Neurosci, 16: 1728-30. Su, C. H., D. D, and W. Y. Tarn. 2018. 'Alternative Splicing in Neurogenesis and Brain Development', Front Mol Biosci, 5: 12. Sugiyama, T., N. Osumi, and Y. Katsuyama. 2013. 'The germinal matrices in the developing dentate gyrus are composed of neuronal progenitors at distinct differentiation stages', Dev Dyn, 242: 1442-53. Sultan, S., L. Li, J. Moss, F. Petrelli, F. Casse, E. Gebara, J. Lopatar, F. W. Pfrieger, P. Bezzi, J. Bischofberger, and N. Toni. 2015. 'Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes', Neuron, 88: 957-72. Sun, B., B. Halabisky, Y. Zhou, J. J. Palop, G. Yu, L. Mucke, and L. Gan. 2009. 'Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease', Cell Stem Cell, 5: 624-33. Toomes, C., H. M. Bottomley, R. M. Jackson, K. V. Towns, S. Scott, D. A. Mackey, J. E. Craig, L. Jiang, Z. Yang, R. Trembath, G. Woodruff, C. Y. Gregory-Evans, K. Gregory-Evans, M. J. Parker, G. C. Black, L. M. Downey, K. Zhang, and C. F. Inglehearn. 2004. 'Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q', Am J Hum Genet, 74: 721-30. Tsai, T. C., Y. L. Lee, W. C. Hsiao, Y. P. Tsao, and S. L. Chen. 2005. 'NRIP, a novel nuclear receptor interaction protein, enhances the transcriptional activity of nuclear receptors', J Biol Chem, 280: 20000-9. Urano, Y., M. Iiduka, A. Sugiyama, H. Akiyama, K. Uzawa, G. Matsumoto, Y. Kawasaki, and F. Tashiro. 2006. 'Involvement of the mouse Prp19 gene in neuronal/astroglial cell fate decisions', J Biol Chem, 281: 7498-514. Urban, N., and F. Guillemot. 2014. 'Neurogenesis in the embryonic and adult brain: same regulators, different roles', Front Cell Neurosci, 8: 396. Vallee, A., and Y. Lecarpentier. 2016. 'Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma', Front Neurosci, 10: 459. Varela-Nallar, L., and N. C. Inestrosa. 2013. 'Wnt signaling in the regulation of adult hippocampal neurogenesis', Front Cell Neurosci, 7: 100. Vidal, R., E. Garro-Martinez, A. Diaz, E. Castro, E. Florensa-Zanuy, M. M. Taketo, A. Pazos, and F. Pilar-Cuellar. 2019. 'Targeting beta-Catenin in GLAST-Expressing Cells: Impact on Anxiety and Depression-Related Behavior and Hippocampal Proliferation', Mol Neurobiol, 56: 553-66. Vorhees, C. V., and M. T. Williams. 2006. 'Morris water maze: procedures for assessing spatial and related forms of learning and memory', Nat Protoc, 1: 848-58. Wan, L., and J. Huang. 2014. 'The PSO4 protein complex associates with replication protein A (RPA) and modulates the activation of ataxia telangiectasia-mutated and Rad3-related (ATR)', J Biol Chem, 289: 6619-26. Weller, J., and A. Budson. 2018. 'Current understanding of Alzheimer's disease diagnosis and treatment', F1000Res, 7. Wexler, E. M., D. H. Geschwind, and T. D. Palmer. 2008. 'Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation', Mol Psychiatry, 13: 285-92. Wissmann, C., P. J. Wild, S. Kaiser, S. Roepcke, R. Stoehr, M. Woenckhaus, G. Kristiansen, J. C. Hsieh, F. Hofstaedter, A. Hartmann, R. Knuechel, A. Rosenthal, and C. Pilarsky. 2003. 'WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer', J Pathol, 201: 204-12. Xia, K., H. Guo, Z. Hu, G. Xun, L. Zuo, Y. Peng, K. Wang, Y. He, Z. Xiong, L. Sun, Q. Pan, Z. Long, X. Zou, X. Li, W. Li, X. Xu, L. Lu, Y. Liu, Y. Hu, D. Tian, L. Long, J. Ou, Y. Liu, X. Li, L. Zhang, Y. Pan, J. Chen, H. Peng, Q. Liu, X. Luo, W. Su, L. Wu, D. Liang, H. Dai, X. Yan, Y. Feng, B. Tang, J. Li, Z. Miedzybrodzka, J. Xia, Z. Zhang, X. Luo, X. Zhang, D. St Clair, J. Zhao, and F. Zhang. 2014. 'Common genetic variants on 1p13.2 associate with risk of autism', Mol Psychiatry, 19: 1212-9. Xu, N., W. J. Zhou, Y. Wang, S. H. Huang, X. Li, and Z. Y. Chen. 2015. 'Hippocampal Wnt3a is Necessary and Sufficient for Contextual Fear Memory Acquisition and Consolidation', Cereb Cortex, 25: 4062-75. Xu, Q., F. Wang, Y. Xiang, X. Zhang, Z. A. Zhao, Z. Gao, W. Liu, X. Lu, Y. Liu, X. J. Yu, H. Wang, J. Huang, Z. Yi, S. Gao, and L. Li. 2015. 'Maternal BCAS2 protects genomic integrity in mouse early embryonic development', Development, 142: 3943-53. Yang, K., X. Wang, H. Zhang, Z. Wang, G. Nan, Y. Li, F. Zhang, M. K. Mohammed, R. C. Haydon, H. H. Luu, Y. Bi, and T. C. He. 2016. 'The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies', Lab Invest, 96: 116-36. Yi, Yandong, Yuanlong Song, and Yisheng Lu. 2020. 'Parvalbumin Interneuron Activation-Dependent Adult Hippocampal Neurogenesis Is Required for Treadmill Running to Reverse Schizophrenia-Like Phenotypes', Frontiers in Cell and Developmental Biology, 8. Zechner, D., Y. Fujita, J. Hulsken, T. Muller, I. Walther, M. M. Taketo, E. B. Crenshaw, 3rd, W. Birchmeier, and C. Birchmeier. 2003. 'beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system', Dev Biol, 258: 406-18. Zeng, Q., Z. Long, M. Feng, Y. Zhao, S. Luo, K. Wang, Y. Wang, G. Yang, and G. He. 2019. 'Valproic Acid Stimulates Hippocampal Neurogenesis via Activating the Wnt/beta-Catenin Signaling Pathway in the APP/PS1/Nestin-GFP Triple Transgenic Mouse Model of Alzheimer's Disease', Front Aging Neurosci, 11: 62. Zhang, N., R. Kaur, S. Akhter, and R. J. Legerski. 2009. 'Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint', EMBO Rep, 10: 1029-35. Zhang, Y., Y. Sun, F. Wang, Z. Wang, Y. Peng, and R. Li. 2012. 'Downregulating the canonical Wnt/beta-catenin signaling pathway attenuates the susceptibility to autism-like phenotypes by decreasing oxidative stress', Neurochem Res, 37: 1409-19. Zhao, C., W. Deng, and F. H. Gage. 2008. 'Mechanisms and functional implications of adult neurogenesis', Cell, 132: 645-60. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/51720 | - |
dc.description.abstract | BCAS2是一個26kDa大小的核蛋白,它是腫瘤抑制因子p53的負調控者,參與在細胞的生長調節,並且也是Prp19/CDC5L RNA剪切複合體的核心蛋白,為pre-mRNA剪切活動所必需。我們實驗室先前的研究發現BCAS2會參與調控β-catenin pre-mRNA 的剪切,進而影響β-catenin蛋白表現,在透過CaMKIIα驅動而產生BCAS2缺乏的BCAS2條件式基因剔除小鼠中,我們發現β-catenin蛋白表現有顯著降低,並且伴隨海馬迴中齒狀迴內新生神經樹突發育的異常及退化的學習能力與記憶。我們過去利用基因慢病毒載體攜帶shBCAS2對野生型小鼠進行BCAS2敲落,發現神經幹細胞的增生比率被顯著降低,而相對的,對BCAS2條件式基因剔除小鼠進行顱內注射AAV-BCAS2,我們發現神經幹細胞的增生以及β-catenin蛋白表現能夠恢復。由於已有許多報導指出Wnt/β-catenin訊息傳遞鏈的活化會促進神經幹細胞的自我更新以及刺激神經的分化,因此β-catenin普遍被認為在成體神經新生中扮演重要角色。而我們也因此認為BCAS2調控神經幹細胞的增生是透過β-catenin。在本篇研究中,我們首先探討是否DCX+新生神經的生長也會受到BCAS2影響,而結果顯示在BCAS2條件式剔除小鼠及BCAS2敲落小鼠中,DCX+細胞數量都有顯著降低。相對的,顱內注射AAV-BCAS2則回復了BCAS2條件式剔除小鼠中DCX+細胞數量,結果指出BCAS2確實也參與在神經分化的調控中。另外,為了探討BCAS2透過β-catenin調控成體神經新生的假設,我們設計利用AAV-β-catenin注射BCAS2條件式剔除小鼠以強行表現β-catenin的方式能否改善神經新生。結果透過神經幹細胞指標Sox2、DNA合成指標BrdU、未成熟神經細胞指標DCX及增生活動指標Ki67,顯示神經幹細胞的增生、新生神經的分化都有顯著提升。此外,我們發現AAV-β-catenin不只能夠感染神經前驅細胞並造成自泌作用,也能夠感染星狀膠質細胞及中間神經元,而這可能會導致對成體神經新生活動的旁泌作用。由於Wnt/β-catenin的活化曾經被報導過可能在阿茲海默症中具有保護神經元的潛力,且在阿茲海默症疾病模式APP J20小鼠中有退化的神經新生現象,我們利用APP J20阿茲海默症疾病模式小鼠作為探討AAV-β-catenin在阿茲海默症神經新生中所扮演角色的模型。我們首先檢查了實驗室所培育的APP J20小鼠其神經新生的情形,然而只發現輕微的Sox2+及DCX+細胞減少。也因此,顱內注射AAV-β-catenin並沒有辦法在此品系之APP J20小鼠中達成促進神經新生或其他影響的效果。 | zh_TW |
dc.description.abstract | Breast Carcinoma Amplified Sequence 2 (BCAS2) is a 26 kDa nuclear protein and a negative regulator of tumor suppressor p53. BCAS2 participates in cell growth regulation and it is a core membrane of Prp19/CDC5L spliceosome complex, therefore essential for pre-mRNA splicing. Previous studies in our lab have shown that BCAS2 regulate β-catenin pre-mRNA splicing, thence β-catenin protein level reduces when BCAS2 depletion in CaMKIIα driven BCAS2 cKO mice. Moreover, lack of BCAS2 interrupts dendrite development in newborn neurons in DG of hippocampus as well as displays impaired learning and memory. We previously find reduced percentage of proliferating NSCs in lenti-shBCAS2 intracranial injected WT mice and the proliferation of NSCs and β-catenin level were rescued after injecting AAV-BCAS2 into DG of BCAS2 cKO mice. The role of β-catenin in adult neurogenesis has been well documented. Wnt/β-catenin signaling promotes self-renewal of neuron stem cells as well as induces differentiation, we hypothesize that BCAS2 regulates NSCs proliferation via β-catenin. In this study, we determine whether the growth of DCX+ newborn neurons would also be affected by BCAS2. Data show impaired number of DCX+ neurons in both BCAS2 cKO mice and lentivirus mediated BCAS2 knockdown mice, while DCX+ neurons restore after intracranial injecting AAV-BCAS2 into DG of BCAS2 cKO mice. Results indicate that BCAS2 regulates neuron differentiation, too. To verify the hypothesis that BCAS2 affects adult neurogenesis directly through β-catenin, we examine whether forced expression of β-catenin could improve adult neurogenesis in BCAS2 cKO mice. Consequently, we generate AAV9-β-catenin and apply it to BCAS2 cKO mice. Results show improving NSCs proliferation and newborn neuron differentiation detected by stem cell marker Sox2, DNA synthesis marker BrdU, immature neuron marker DCX and proliferating marker Ki67. Besides, we find that AAV9-β-catenin not only infect into neuron progenitor cells, which represent an autonomous effect, but also infect astrocytes and interneurons, which may induce paracrine effect on neurogenesis. Additionally, due to the potential benefit of neuron protection by activating Wnt/β-catenin in Alzheimer’s disease and the decreasing neurogenesis in APP mice as previous reports, we use APP J20 mice as a disease model to explore the role of AAV-β-catenin in neurogenesis of AD. We determine the situation of adult neurogenesis in elder APP mice firstly and find only a mild impairment in Sox2+ cell number and DCX+ cell number. For this reason, intracranial injection of AAV-β-catenin cannot make improvement or difference on APP J20 mice line breeding by our lab. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T13:46:14Z (GMT). No. of bitstreams: 1 U0001-0908202014084300.pdf: 3454309 bytes, checksum: 35581387149185a232fd7a91efb731b3 (MD5) Previous issue date: 2020 | en |
dc.description.tableofcontents | 口試委員審定書...i 致謝...ii 中文摘要...iii ABSTRACT...v TABLE OF CONTENT...vii CHAPTER 1 INTRODUCTION...1 1.1 The characteristic of BCAS2 and splicing...1 1.2 BCAS2 and neurodegenerative disease...4 1.3 Hippocampal neurogenesis in embryo and adult...6 1.4 Canonical Wnt/β-catenin signaling pathway...9 1.5 Wnt/β-catenin signaling pathway in adult neurogenesis...10 1.6 Alzheimer’s disease...14 1.7 Aim of this study...15 CHAPTER 2 MATERIALS AND METHODS...18 2.1 Mice cohorts...18 2.2 Generation of AAV plasmid...18 2.3 Cell culture, transfection, virus production and purification...20 2.4 Dot blot assay...21 2.5 Brain stereotaxic surgery...24 2.6 Mice behavioral experiments...25 2.7 Tissue preparation...26 2.8 Immunoflurescence assay...26 2.9 BrdU administration...27 2.10 Western blot analysis...28 2.11 Stereological analysis...29 2.12 Statistical analysis...30 CHAPTER 3 RESULTS...31 3.1 DCX+ newborn neurons reduced in hippocampus of BCAS2 cKO mice....31 3.2 DCX+ newborn neurons reduced in hippocampus after BCAS2 knockdown....32 3.3 Intracranial hippocampal injection of AAV-BCAS2 restores the differentiation process of neural progenitors in BCAS2 cKO mice....34 3.4 The generation of recombinant adeno-associated virus (rAAV)-9-CMV-β-catenin....36 3.5 AAV9 virus could efficiently infect into stem cells, astrocytes and interneurons in DG....39 3.6 AAV9-β-catenin could restore number of NSCs and DCX+ newborn neurons....40 3.7 APP mice show poor neurogenesis compared to WT mice....47 3.8 Gain-of-function by AAV9-β-catenin could not improve NSCs proliferation in APP mice....50 CHAPTER 4 DISCUSSION...54 REFERENCE...64 FIGURES...74 SUPPLEMENTARY...96 APPENDIX...97 | |
dc.language.iso | en | |
dc.title | β-catenin在BCAS2條件式剔除小鼠及阿茲海默症疾病模式小鼠中調控成體神經新生過程之角色 | zh_TW |
dc.title | The role of β-catenin in adult neurogenesis of BCAS2 cKO mice and Alzheimer’s disease model (APP) mice | en |
dc.type | Thesis | |
dc.date.schoolyear | 108-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 黃憲松(Hsien-Sung Huang),王培育(Pei-Yu Wang),詹世鵬(Shih-Peng Chan) | |
dc.subject.keyword | BCAS2,β-catenin,成體神經新生,BCAS2條件式基因剔除小鼠(CAMKIIα-Cre,BCAS2flox/flox),阿茲海默症,APP J20阿茲海默症疾病模式小鼠, | zh_TW |
dc.subject.keyword | BCAS2,β-catenin,adult neurogenesis,BCAS2 cKO mice (CAMKIIα-Cre,BCAS2flox/flox),Alzheimer’s disease,APP J20 mice, | en |
dc.relation.page | 98 | |
dc.identifier.doi | 10.6342/NTU202002710 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2020-08-11 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 微生物學研究所 | zh_TW |
顯示於系所單位: | 微生物學科所 |
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