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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 孫璐西 | |
dc.contributor.author | Chia-Hui Chen | en |
dc.contributor.author | 陳家慧 | zh_TW |
dc.date.accessioned | 2021-06-13T04:19:21Z | - |
dc.date.available | 2014-08-02 | |
dc.date.copyright | 2011-08-02 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-07-28 | |
dc.identifier.citation | 第一部分、研究背景與結果討論
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Beneficial effects of IH-901 on glucose and lipid metabolisms via activating adenosine monophosphate-activated protein kinase and phosphatidylinositol-3 kinase pathways. Metabolism 2010. Zhang, C. Y.; Baffy, G.; Perret, P.; Krauss, S.; Peroni, O.; Grujic, D.; Hagen, T.; Vidal-Puig, A. J.; Boss, O.; Kim, Y. B.; Zheng, X. X.; Wheeler, M. B.; Shulman, G. I.; Chan, C. B.; Lowell, B. B. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 2001, 105, 745-755. Zhang, Z. G.; Li, X. Y.; Lv, W. S.; Yang, Y. S.; Gao, H.; Yang, J.; Shen, Y.; Ning, G. Ginsenoside Re kinase and nuclear factor-kappa b. Mol. Endocrinol. 2008, 22, 186-195. Zhou, W.; Yan, Q.; Li, J. Y.; Zhang, X. C.; Zhou, P. Biotransformation of panax notoginseng saponins into ginsenoside compound k production by paecilomyces bainier sp 229. J. Appl. Microbiol. 2008, 104, 699-706. 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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/32929 | - |
dc.description.abstract | 人參與靈芝皆為深受國人喜愛與重視的保健食品,然而當以人參為原料的藥品及健康食品製造的同時,也產生大量的人參殘渣廢棄物。此外,文獻指出人參中最主要的活性成分人參皂苷原有的型態不利於人體吸收代謝。因此若配合具多種分解酵素的食藥用白腐真菌靈芝共同培養,則可以藉由菌絲體酵素的作用使人參皂苷上之糖基選擇性的被分解,成為活性較高且較易被人體吸收之形式。本研究乃以「人參渣固態培養靈芝」之產物〈人參靈芝發酵產物〉為試驗材料,以不同接菌量及培養天數為變因,進行脂肪細胞攝取葡萄糖的能力評估,與活性成分人參皂苷及多酚之分析,期能明瞭產物於不同培養條件下,其化學成分對生物活性的影響。結果顯示,人參靈芝發酵產物於發酵第八天以及第十三天,樣品濃度為 200 ppm時,能夠顯著提高成熟脂肪細胞 (3T3-L1 adipocytes) 28至45%之葡萄糖攝取量,比發酵前原料人參渣提高10%更有效,且此類似胰島素作用的活性於三種不同接菌量下,在不同發酵天數皆能觀察到。本研究亦探討七種已於文獻上顯示其具有調節血糖能力的人參皂苷組成變化,發現於發酵至十三天時,Rg1, Rg3以及CK之總和相對於七種人參皂苷之總和,從發酵前的2% 提高為30至35%;Re、Rb1、Rc以及Rh2則由98%下降65至70%。此外,於發酵期間同時觀察到β-glucosidase活性顯著提高,可能為轉換人參皂苷的主要酵素來源之一。依據以上結果,推測發酵至第十三天的人參靈芝發酵產物,相較於原人參殘渣更具有效提高脂肪細胞攝取葡萄糖的能力,乃因發酵後人參皂苷Rg1、Rg3及CK於產物中的比例提高。 | zh_TW |
dc.description.abstract | Ginseng is a valuable herb which is popularly used in Traditional Chinese Medicine and functional food products in many Asian countries. Because of the high consumer demand of ginseng products, considerable amount of waste has been generated after extraction of ginseng; however, the lots of bioactive compounds still remained in the waste. The goal of this study was to utilize the ginseng extraction waste as the fermentation medium of G. lucidum to produce bioactive ginsenoside enriched bioconversion products with fermentation technology. We evaluated the hypoglycemic activity of the fermented products and developed an appropriate cultured condition for the bioconversion of ginsenosides. Fermented products at dose of 200 ppm induced higher glucose uptake in adipocytes than original ginseng waste. Ginsenosides Re, Rb1, Rc, and Rh2 showed a trend to decrease while Rg1, Rg3 and CK increased during the fermentation process, at the same time we observed higher β-glucosidase activity after the fermentation. The elevated activity of glucose uptake by the fermented ginseng products in adipocytes may be due to the increasing amounts of Rg1, Rg3 and CK after the fermentation process. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T04:19:21Z (GMT). No. of bitstreams: 1 ntu-100-R98641008-1.pdf: 2189682 bytes, checksum: 6494b30acba85f4b0421dd980cf91b49 (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | 中文摘要 I
英文摘要 II 縮寫表 III 目錄 V 圖次 VII 表次 IX 壹、前言 1 貳、文獻整理 3 第一節、人參植物概況與成分 3 第二節、人參皂苷與其生理活性 4 第三章、人參與人參皂苷於調節血糖的研究 7 一、葡萄糖在體內的代謝 7 二、糖尿病簡介 12 三、人參與人參皂苷於調節血糖的研究 12 第四節、人參皂苷之生物轉換 17 第五節、靈芝概況 19 第六節、靈芝培養 22 參、研究目的與實驗架構 23 第一節、研究目的 23 第二節、實驗架構 24 肆、材料與方法 25 第一節、實驗材料與儀器設備 25 一、人參渣 25 二、人參靈芝菌絲固體培養產物 (人參靈芝發酵產物) 25 三、實驗細胞株 25 四、試劑與試藥 25 五、細胞實驗各種溶液配方 29 七、化學分析儀器設備 31 八、細胞實驗儀器設備 33 九、實驗耗材 33 第二節、實驗方法 35 一、樣品前處理 35 二、樣品的萃取與純化 35 三、活性成分分析 36 (一) 人參皂苷之高效能液相層析儀 (HPLC) 分析條件 36 (二) 人參皂苷檢量線測定 36 (三) 樣品回收率 37 (四) 總多酚化合物含量測定 37 四、β-glucosidase 活性之測定 37 五、以脂肪細胞模式進行葡萄糖攝取試驗 38 (一) 前脂肪細胞 3T3-L1 之培養 38 (二) 細胞繼代及冷凍保存 38 (三) 前脂肪細胞3T3-L1之分化培養 39 (四) 前脂肪細胞3T3-L1之油紅 (Oil red O) 染色 39 (五) 細胞存活率測定─MTT assay 40 (六) 葡萄糖攝取測定法 40 第三節、統計分析 41 伍、結果 42 第一節、人參靈芝發酵產物萃出物之萃取與純化 42 第二節、人參靈芝發酵產物之人參皂苷組成之變化 44 第三節、人參靈芝發酵產物之總多酚含量之變化 57 第四節、 β-葡萄糖苷酶 (β-glucosidase) 於人參靈芝發酵產物發酵期間之活性變化 59 第五節、人參靈芝發酵產物之生物活性評估 61 一、脂肪細胞分化方法以及葡萄糖攝取試驗之細胞模式確立 61 二、人參皂苷於脂肪細胞攝取葡萄糖試驗 64 三、人參靈芝發酵產物對於脂肪細胞攝取葡萄糖的影響 69 陸、綜合討論 77 第一節、前言 77 第二節、人參皂苷發酵產物對於脂肪細胞攝取葡萄糖的影響 78 第三節、人參靈芝發酵產物中人參皂苷組成變化與總多酚含量變化對於脂肪細胞攝取葡萄糖能力的影響 81 第四節、β-glucosidase活性與人參皂苷生物轉化的影響 85 柒、結論 87 捌、參考文獻 88 第一部分、研究背景與結果討論 88 第二部分、研究方法 98 玖、附錄 100 | |
dc.language.iso | zh-TW | |
dc.title | 人參皂苷生物轉化物對脂肪細胞攝取葡萄糖的影響 | zh_TW |
dc.title | Effect of Ginsenoside Catabolites on Glucose Uptake in 3T3-L1 Adipocytes | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 顏國欽,黃青真,吳亮宜,呂廷璋,何其儻 | |
dc.subject.keyword | 人參皂苷,赤芝,生物轉化,T3-L1脂肪細胞,葡萄糖攝取, | zh_TW |
dc.subject.keyword | ginsenoside,Ganoderma lucidum,bioconversion,3T3-L1 adipocytes, | en |
dc.relation.page | 120 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2011-07-28 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 食品科技研究所 | zh_TW |
顯示於系所單位: | 食品科技研究所 |
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