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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 沈雅敬 | |
dc.contributor.author | Pei-Hsin Li | en |
dc.contributor.author | 李沛心 | zh_TW |
dc.date.accessioned | 2021-06-08T03:53:22Z | - |
dc.date.copyright | 2018-10-03 | |
dc.date.issued | 2018 | |
dc.date.submitted | 2018-08-17 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/21924 | - |
dc.description.abstract | 本論文研究台灣特有種阿里山五味子 (Schisandra arisanensis Hayata)藤莖的乙醇萃取物,並分析鑑定其所含之木酚素成分。共分離出二十一個成分,包含十九個木酚素與兩個倍半萜類。
本實驗得到之成分中有三個新成分1-3,其中化合物1和3為木酚素,二者各有C18 dibenzocyclooctadiene和dihydrobenzofuran的骨架,一個倍半萜類化合物2。此次分離到的已知倍半萜為2-hydoxy-11, 12-dehydrocalamenene (4),十七個已知木酚素成分有:isoanwulignan (5)、methylgomisin R (6)、interiotherin B (7)、schisantherin D (8)、3',4'-dimethoxybenzoic acid (3',4'-dimethoxyphenyl)-2-methyl-3-oxobutyl ester (9)、gomisin G (10)、12-demethylwuweilignan I (11)、arisanschinin E (12)、(+)-fragransin A2 (13)、(+)-verrucosin (14)、gomisin J (15)、machilin D (16)、rubrisandrin A (17)、gomisin E (18)、kadsuphilin B (19)、arisanschinin F (20)、dihydrodehydrodiconiferyl alcohol (21)。 新成分和已知成分經過一維和二維核磁共振圖譜 (COSY, HMQC, HMBC, NOESY)、紅外線、紫外線線、圓二色性光譜、高解析電灑式質譜以及旋光值之測定,參閱Reaxys電子資料庫相似化合物和Web of Science之文獻後建立化學結構。 將所得的化合物 (1–21)進行抗發炎、抗癌細胞與抗氧化活性測試與評估。 | zh_TW |
dc.description.abstract | This thesis focused on the investigation of an ethanol extract from stems of Schisandra arisanensis Hayata, an endemic species in Taiwan. Fractionation of the extract has resulted in the isolation of twenty-one compounds, including nineteen lignans and two sesquiterpenes.
Three new compounds (1-3) containing a dibenzocyclo-octadiene lignan with a C18 skeleton, a sesquiterpenoid, and a dihydrobenzofuran 8,3'-lignan were reported here. Others were known compounds, including 2-hydoxy-11, 12-dehydrocalamenene (4), isoanwulignan (5), methylgomisin R (6), interiotherin B (7), schisantherin D (8),3',4'-dimethoxybenzoic acid (3',4'-dimethoxyphenyl)-2-methyl-3-oxobutyl ester (9), gomisin G (10), 12-demethylwuweilignan I (11), arisanschinin E (12), (+)-fragransin A2 (13), (+)-verrucosin (14), gomisin J (15), machilin D (16), rubrisandrin A (17), gomisin E (18), kadsuphilin B (19), arisanschinin F (20), dihydrodehydrodiconiferyl alcohol (21). The structures of these new compounds were established on the basis of spectroscopic methods, especially 2D NMR (COSY, HMQC, HMBC, NOESY), and high-resolution ESI-MS, infrared, ultraviolet, CD, and specific optical rotation. In addition, searching for the related compound in Reaxys database and reference reports from Web of Science were necessary to elucidate the structures. All anti-inflammatory bioactivities, anti-tumor cytotoxicities, and anti-oxidation activities of the compounds were tested and evaluated. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T03:53:22Z (GMT). No. of bitstreams: 1 ntu-107-R03423022-1.pdf: 16721281 bytes, checksum: fe0de36bcb620cdfc041db7898409986 (MD5) Previous issue date: 2018 | en |
dc.description.tableofcontents | 誌謝 i
中文摘要 ii 英文摘要 iii 第一章 序論 1 第一節 前言 1 第二節 相關化合物之文獻回顧 3 第二章 材料及方法 46 第一節 材料介紹 46 第二節 分離流程 47 第三節 實驗儀器 56 第四節 實驗溶劑及矽膠 58 第三章 實驗結果 59 第一節 化合物1之結構解析 60 第二節 化合物2之結構解析 65 第三節 化合物3之結構解析 71 第四節 化合物4之結構 76 第五節 化合物5之結構 77 第六節 化合物6之結構 78 第七節 化合物7之結構 79 第八節 化合物8之結構 80 第九節 化合物9之結構 81 第十節 化合物10之結構 82 第十一節 化合物11之結構 83 第十二節 化合物12之結構 84 第十三節 化合物13之結構 85 第十四節 化合物14之結構 86 第十五節 化合物15之結構 87 第十六節 化合物16之結構 88 第十七節 化合物17之結構 89 第十八節 化合物18之結構 90 第十九節 化合物19之結構 91 第二十節 化合物20之結構 92 第二十一節 化合物21之結構 93 第二十二節 抗發炎活性之測試 94 第二十三節 抗癌活性之測試 96 第二十四節 抗氧化活性之測試 98 第四章 結論 100 參考文獻 101 附錄一:NMR圖譜 114 附錄二:IR、CD光譜、MS圖譜 124 | |
dc.language.iso | zh-TW | |
dc.title | 阿里山五味子藤莖活性木酚素成分之研究 | zh_TW |
dc.title | Studies on the Bioactive Lignans from stems of
Schisandra arisanensis Hayata | en |
dc.type | Thesis | |
dc.date.schoolyear | 106-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 郭曜豪,鄭源斌 | |
dc.subject.keyword | 阿里山五味子,藤莖,木酚素,倍半?, | zh_TW |
dc.subject.keyword | Schisandra arisanensis,stems,lignans,sesquiterpenes, | en |
dc.relation.page | 130 | |
dc.identifier.doi | 10.6342/NTU201803850 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2018-08-17 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 藥學研究所 | zh_TW |
顯示於系所單位: | 藥學系 |
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